White Judith, Savvides Panos, Cherian Neil, Oas John
Section of Vestibular and Balance Disorders, Head and Neck Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA.
Otol Neurotol. 2005 Jul;26(4):704-10. doi: 10.1097/01.mao.0000178128.66482.7e.
To evaluate the efficacy of canalith repositioning maneuvers (Semont, Epley, and modified maneuvers) in the treatment of posterior canal benign paroxysmal positional vertigo (BPPV) in comparison to the rate of resolution in the untreated control cohort.
Source articles were identified by a MEDLINE search of English language sources before 2004 plus manual crosschecks of bibliographies from identified articles, selected national meeting abstracts, review article references, and textbook chapters.
Each controlled trial that compared canalith repositioning patients to untreated control subjects in posterior canal benign positional vertigo (blinded and unblinded) was reviewed for inclusion.
Data were abstracted systematically, scaled on validity and comparability, and cross-checked independently by another author.
Studies were combined with fixed effects meta-analysis to estimate spontaneous resolution, 95% confidence intervals (CI) of effect size, and heterogeneity.
Canalith repositioning is more effective than observation alone for the treatment of benign paroxysmal positional vertigo, despite spontaneous resolution rates of one in three at 3 weeks. Public health implications are discussed, based on the high frequency of unrecognized BPPV reported in elderly patients, and the improvements after canalith repositioning in postural control and health-related quality of life (SF 36 Health Survey) documented in the literature.
与未经治疗的对照队列的缓解率相比,评估半规管结石复位手法(Semont法、Epley法及改良手法)治疗后半规管良性阵发性位置性眩晕(BPPV)的疗效。
通过检索2004年前的英文MEDLINE文献以及对已识别文章的参考文献、选定的全国会议摘要、综述文章参考文献和教科书章节进行人工交叉核对来识别原始文章。
纳入每项比较后半规管良性位置性眩晕患者接受半规管结石复位治疗与未经治疗的对照受试者(有盲法和无盲法)的对照试验。
系统提取数据,根据有效性和可比性进行评分,并由另一位作者独立交叉核对。
采用固定效应荟萃分析合并研究,以估计自然缓解率、效应大小的95%置信区间(CI)及异质性。
尽管3周时自然缓解率为三分之一,但半规管结石复位治疗良性阵发性位置性眩晕比单纯观察更有效。基于老年患者中未被识别的BPPV的高发生率以及文献中记录的半规管结石复位后姿势控制和健康相关生活质量(SF 36健康调查)的改善情况,讨论了对公共卫生的影响。