Juergens Kai Uwe, Reimer Peter, Weber Thomas Peter, Tombach Bernd, Bremer Christoph, Renger Bernhard, Aken Hugo Van, Heindel Walter
Department of Clinical Radiology, University of Muenster, Albert-Schweitzer-Strasse 33, D-48149 Muenster, Germany.
Int J Cardiovasc Imaging. 2005 Apr-Jun;21(2-3):271-82. doi: 10.1007/s10554-004-2459-x.
We investigated the potential of Cine and 2D Tagged Cardiac Magnetic Resonance (CMR) Imaging to distinguish stunned from necrotic left ventricular (LV) myocardium in the early postischemic phase in an open-chest animal model (N = 12). Reversible and permanent occlusion of the LAD coronary artery resulted in global LV dysfunction in both groups without significant differences. LAD perfused segments revealed significant higher values for end systolic wall thickening (ESWT) and percentual systolic wall thickening in animals with stunned myocardium. Analysis of strain parameters showed significant regional differences (maximal principal strain lambda1, deviation angle beta) between postischemic and remote myocardium within both groups, however results were not significantly different comparing animals with stunned myocardium to animals with myocardial necrosis. In conclusion, at rest neither global LV functional nor regional strain parameters derived from Cine and 2D Tagged CMR Imaging can distinguish animals with short-term stunned myocardium from respective animals with necrotic myocardium. Diagnostic value of ESWT is limited due to the spatial resolution of the gradient-echo sequence used.
我们在开胸动物模型（N = 12）中研究了电影磁共振成像（Cine）和二维标记心脏磁共振成像（CMR）区分缺血后早期左心室（LV）心肌顿抑与坏死的潜力。两组中左前降支（LAD）冠状动脉的可逆性和永久性闭塞均导致整体左心室功能障碍，且无显著差异。在心肌顿抑的动物中，LAD灌注节段的收缩末期壁增厚（ESWT）和收缩期壁增厚百分比显著更高。应变参数分析显示两组中缺血后心肌与远隔心肌之间存在显著的区域差异（最大主应变λ1、偏差角β），然而，将心肌顿抑的动物与心肌坏死的动物进行比较，结果并无显著差异。总之，静息状态下，来自电影磁共振成像和二维标记心脏磁共振成像的整体左心室功能参数或区域应变参数均无法区分短期心肌顿抑的动物与相应的心肌坏死动物。由于所使用的梯度回波序列的空间分辨率，ESWT的诊断价值有限。
