Endo H, Kumabe T, Jokura H, Tominaga T
Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Minim Invasive Neurosurg. 2005 Jun;48(3):186-90. doi: 10.1055/s-2004-830263.
Intracranial germinomas can be cured by radiotherapy and/or chemotherapy. Three patients with pineal germinoma were treated with stereotactic radiosurgery using the gamma knife (10 - 12 Gy) to the tumors followed by whole ventricular irradiation (24 Gy). All patients had solitary pineal tumor measuring less than 3 cm, clinically compatible with germinoma, normal cerebrospinal fluid (CSF) and serum levels of alpha-fetoprotein and beta-human chorionic gonadotropin, no disseminated disease on spinal magnetic resonance (MR) imaging, and no abnormal CSF cytology. All patients showed complete response to the combined radiotherapy, and MR imaging has shown no recurrence of the tumor. Combined radiotherapy using gamma knife radiosurgery is effective for pineal germinoma, and reduced the cost of treatment with less need for hospitalization.
颅内生殖细胞瘤可通过放疗和/或化疗治愈。三名松果体生殖细胞瘤患者接受了伽玛刀立体定向放射外科治疗（肿瘤剂量10 - 12 Gy），随后进行全脑室照射（24 Gy）。所有患者均有单个松果体肿瘤，直径小于3 cm，临床符合生殖细胞瘤表现，脑脊液（CSF）及血清甲胎蛋白和β-人绒毛膜促性腺激素水平正常，脊柱磁共振（MR）成像未发现播散性病变，CSF细胞学检查无异常。所有患者对联合放疗均显示完全缓解，MR成像显示肿瘤无复发。伽玛刀放射外科联合放疗对松果体生殖细胞瘤有效，且降低了治疗成本，减少了住院需求。
