Darvesh S, Leach L, Black S E, Kaplan E, Freedman M
Department Neurology and Geriatric Medicine, Dalhousie University, Halifax, NS, Canada.
Can J Neurol Sci. 2005 May;32(2):167-77. doi: 10.1017/s0317167100003930.
We present information regarding the standardization, reliability and clinical validity of two versions of the Behavioural Neurology Assessment (BNA). The BNA-Long Form consists of 24 subtests within separate domains: Attention, Memory, Language, Visuospatial Function, Executive Function, and Praxis. The BNA-Short Form consists of 13 subtests within the domains of Attention, Memory, Naming, Visuospatial Function and Executive Function. In addition to individual domain indices, a Grand Total score was calculated for both BNA versions.
To standardize the administration and scoring and validate the BNA for detection of dementia.
Standardized normative data were obtained on 115 healthy subjects ranging in age from 50 to 95. Test-retest stability was obtained on 19 subjects and clinical validity was investigated by administering the BNA and Mini-Mental Status Examination (MMSE) to 29 patients with dementia and 29 age-matched healthy subjects (controls).
Age had a significant effect on all but the Visuospatial and Praxis indices of the BNA-Long Form and an effect on Naming and Grand Total score of the Short-Form. Internal consistency (Cronbach's coefficient alpha) was .87 and .67 for the Long and Short Forms (.95 and .96 for dementia and control groups combined). Test-retest stability was acceptable. Grand Total indices of both BNA versions showed significant, positive correlations with the MMSE. Both BNA versions had superior sensitivity to dementia relative to the MMSE (.93 versus .79). Specificity was equivalent to the MMSE (.93 versus .97).
Positive predictive values of the BNA and MMSE are equivalent but the BNA provides superior negative predictive value.
我们提供了关于两种版本的行为神经病学评估（BNA）的标准化、可靠性和临床有效性的信息。BNA长式包括24个分测验，分属于不同领域：注意力、记忆、语言、视觉空间功能、执行功能和运用能力。BNA短式包括13个分测验，分属于注意力、记忆、命名、视觉空间功能和执行功能领域。除了各个领域的指数外，还计算了两种BNA版本的总分。
规范BNA的施测和评分，并验证其用于痴呆检测的有效性。
获取了115名年龄在50至95岁之间的健康受试者的标准化常模数据。对19名受试者进行了重测稳定性测试，并通过对29名痴呆患者和29名年龄匹配的健康受试者（对照组）施测BNA和简易精神状态检查表（MMSE）来研究临床有效性。
年龄对BNA长式中除视觉空间和运用能力指数外的所有指数均有显著影响，对短式的命名和总分有影响。长式和短式的内部一致性（克朗巴赫α系数）分别为0.87和0.67（痴呆组和对照组合并后为0.95和0.96）。重测稳定性可以接受。两种BNA版本的总分指数与MMSE均呈显著正相关。相对于MMSE，两种BNA版本对痴呆的敏感性更高（分别为0.93和0.79）。特异性与MMSE相当（分别为0.93和0.97）。
BNA和MMSE的阳性预测值相当，但BNA的阴性预测值更高。
