钯催化的大岛-宇田本反应立体选择性合成呋喃
Stereoselective synthesis of furans by the Pd-catalyzed Oshima-Utimoto reaction.
作者信息
Evans Michael A, Morken James P
机构信息
Department of Chemistry, The University of North Carolina at Chapel Hill, 27599-3290, USA.
出版信息
Org Lett. 2005 Jul 21;7(15):3367-70. doi: 10.1021/ol051275s.
PMID:16018662
Abstract
[reaction: see text]. The Pd-catalyzed coupling of acyclic allylic alcohols with vinyl ethers was examined and found to proceed with 2.5-10 mol % of catalyst and to provide cyclic acetals with good stereoselection. The reaction is tolerant of a number of functional groups and can be used to generate quaternary centers in a stereoselective fashion.
摘要
[反应：见正文]。研究了钯催化的无环烯丙醇与乙烯基醚的偶联反应，发现该反应在2.5 - 10 mol%的催化剂存在下进行，并能以良好的立体选择性提供环状缩醛。该反应对多种官能团具有耐受性，可用于以立体选择性方式生成季碳中心。
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