Leask Stuart J, Crow Timothy J
Nottingham University Department of Psychiatry, Duncan Macmillan House, Porchester Road, Nottingham, NG3 6AA, UK.
Psychiatry Res. 2005 Jul 15;136(1):35-42. doi: 10.1016/j.psychres.2004.06.020.
Deficits in lateralization have been reported in handedness, language and anatomical asymmetry in schizophrenia, but the relationship between these anomalies has been unclear. Extending earlier work demonstrating that degrees of lateralization are related to verbal ability in the general population, we here investigate the relationship in children who later developed psychosis. Using data from a box-marking test and an index of receptive verbal ability in the UK National Child Development study, we constructed three-dimensional plots of verbal ability in relation to left- and right-hand skill at the age of 11 years, and compared the performance of 34 children who by age 28 had developed schizophrenia and 21 who had developed affective psychosis with 12,782 in the total population. In the total population, verbal skill is decreased in those who are close to the L=R line. Children premorbid for schizophrenia are less lateralized and their verbal skill is lower than predicted by their hand skill, with a similar trend in children premorbid for affective psychosis. Thus pre-psychotic children deviate from the general population in the trajectory of lateralization of words. The findings are consistent with the concept that in psychosis at some critical stage in development there is a failure of lateralization of the components of language.
精神分裂症患者在利手、语言和解剖学不对称方面的偏侧化缺陷已有报道，但这些异常之间的关系尚不清楚。早期研究表明，在普通人群中，偏侧化程度与语言能力有关，在此基础上，我们对后来发展为精神病的儿童的这种关系进行了研究。利用英国国家儿童发展研究中的一项画盒测试数据和接受性语言能力指标，我们绘制了11岁儿童语言能力与左右手技能关系的三维图，并将34名28岁时患精神分裂症的儿童和21名患情感性精神病的儿童的表现与总人群中的12782名儿童进行了比较。在总人群中，接近L = R线的人的语言技能较低。精神分裂症病前儿童的偏侧化程度较低，其语言技能低于根据其手技能预测的水平，情感性精神病病前儿童也有类似趋势。因此，精神病前儿童在语言偏侧化轨迹上与普通人群不同。这些发现与这样的概念一致，即在精神病发展的某个关键阶段，语言成分的偏侧化出现了失败。
