Zhang Zhenhuan, Yamashita Hiroko, Toyama Tatsuya, Sugiura Hiroshi, Ando Yoshiaki, Mita Keiko, Hamaguchi Maho, Hara Yasuo, Kobayashi Shunzo, Iwase Hirotaka
Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Kawasumi 1, Nagoya 467-8601, Japan.
Cancer Lett. 2006 Jun 8;237(1):123-9. doi: 10.1016/j.canlet.2005.05.046. Epub 2005 Jul 12.
The transcriptional function of estrogen receptor alpha (ERalpha) can be modulated by co-regulatory proteins. In the present study, therefore, the level of expression of one of the co-regulator Nuclear Receptor Co-repressor 1 (NCOR1) mRNA has been assessed by quantitative real-time RT-PCR in 160 cases of invasive breast carcinoma. It was found that NCOR1 mRNA was expressed at significantly higher levels in patients over 50 years of age, without axillary lymph node involvement, with tumor size less than 2 cm, with low or intermediate histological grade, with ERalpha/PgR-positive and with HER2 negative tumors. Patients with high levels of expression of NCOR1 mRNA have a better prognosis than those with low expression. Univariate and multivariate prognostic analysis demonstrated that NCOR1 mRNA is an independent prognostic factor for breast cancer.
雌激素受体α（ERα）的转录功能可被共调节蛋白调控。因此，在本研究中，通过定量实时逆转录聚合酶链反应（RT-PCR）评估了共调节因子之一核受体共抑制因子1（NCOR1）mRNA在160例浸润性乳腺癌中的表达水平。结果发现，NCOR1 mRNA在年龄超过50岁、无腋窝淋巴结转移、肿瘤大小小于2 cm、组织学分级为低或中级、ERα/PgR阳性且HER2阴性的肿瘤患者中表达水平显著更高。NCOR1 mRNA高表达的患者比低表达患者预后更好。单因素和多因素预后分析表明，NCOR1 mRNA是乳腺癌的独立预后因素。
