Gazitt Yair, Akay Cagla
Department of Medicine/Hematology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA.
Hematology. 2005 Jun;10(3):205-13. doi: 10.1080/10245330500067090.
The proven efficacy of ATO in the treatment of APL and the emerging importance of ATO in other diseases prompted extensive studies of the mechanisms of action of ATO in APL and in other types of cancers. In this review we will focus on downstream events in ATO-induced intrinsic and extrinsic apoptotic pathways with an emphasis on the role of pro-apoptotic and anti-apoptotic proteins and the role of p53 in ATO-induced apoptosis including its effect on cell cycle, its anti-mitotic effect and the role of apoptosis inducing factors (AIF) in ATO-induced apoptosis, chromatin condensation and nuclear fragmentation in myeloma cells as a model.
三氧化二砷（ATO）治疗急性早幼粒细胞白血病（APL）的疗效已得到证实，且ATO在其他疾病中的重要性日益凸显，这促使人们对ATO在APL及其他类型癌症中的作用机制展开广泛研究。在本综述中，我们将聚焦于ATO诱导的内源性和外源性凋亡途径中的下游事件，重点关注促凋亡蛋白和抗凋亡蛋白的作用，以及p53在ATO诱导的凋亡中的作用，包括其对细胞周期的影响、抗有丝分裂作用，以及以骨髓瘤细胞为模型，探讨凋亡诱导因子（AIF）在ATO诱导的凋亡、染色质浓缩和核碎裂中的作用。
