Seiter Karen, Qureshi Anila, Liu Delong, Galvin-Parton Patricia, Arshad Muhammad, Agoliati Glen, Ahmed Tauseef
Zalmen A. Arlin Cancer Institute, New York Medical College, Valhalla, NY 10595, USA.
Leuk Lymphoma. 2005 Jul;46(7):1091-5. doi: 10.1080/10428190500102688.
Werner's syndrome is an autosomal recessive disorder resulting in premature aging. Most patients die in their fifth decade from malignancies or heart disease. The gene for Werner's syndrome (WRN) encodes a recQ helicase. Cells from patients with Werner's syndrome have increased sensitivity to DNA-damaging drugs in vitro. Here we present a patient with Werner's syndrome who developed severe chemotherapy-induced toxicity during treatment for acute myelogenous leukemia. We propose that lack of WRN resulted in increased sensitivity of the patient's cells to the toxicity of chemotherapy.
沃纳综合征是一种常染色体隐性疾病，会导致早衰。大多数患者在五十多岁时死于恶性肿瘤或心脏病。沃纳综合征（WRN）基因编码一种recQ解旋酶。体外实验中，沃纳综合征患者的细胞对DNA损伤药物的敏感性增加。本文报告了一名患有沃纳综合征的患者，其在急性髓性白血病治疗期间发生了严重的化疗诱导毒性反应。我们认为，WRN的缺失导致了患者细胞对化疗毒性的敏感性增加。
