HIV 感染、艾滋病和抗逆转录病毒治疗对口、泪腺外分泌发病机制的影响。
Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands.
机构信息
School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
Vision Research Center, Department of Ophthalmology, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
出版信息
Int J Mol Sci. 2018 Sep 13;19(9):2747. doi: 10.3390/ijms19092747.
Abstract
The structure and function of exocrine glands are negatively affected by human immunodeficiency virus (HIV) infection and its co-morbidities, including innate and adaptive immune responses. At the same time, exocrine function may also be influenced by pharmacotherapies directed at the infectious agents. Here, we briefly review the role of the salivary glands and lacrimal glands in normal physiology and exocrine pathogenesis within the context of HIV infection and acquired immune deficiency syndrome (AIDS), including the contribution of antiretroviral therapies on both. Subsequently, we discuss the impact of HIV infection and the types of antiretroviral therapy on disease management and therapy development efforts.
摘要
外分泌腺的结构和功能会受到人类免疫缺陷病毒 (HIV) 感染及其合并症的影响，包括先天和适应性免疫反应。同时，外分泌功能也可能受到针对感染因子的药物治疗的影响。在这里，我们简要回顾了唾液腺和泪腺在 HIV 感染和获得性免疫缺陷综合征 (AIDS) 背景下的正常生理学和外分泌发病机制中的作用，包括抗逆转录病毒疗法对此两者的影响。随后，我们讨论了 HIV 感染和抗逆转录病毒治疗类型对疾病管理和治疗开发工作的影响。
相似文献
1
Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands.HIV 感染、艾滋病和抗逆转录病毒治疗对口、泪腺外分泌发病机制的影响。
Int J Mol Sci. 2018 Sep 13;19(9):2747. doi: 10.3390/ijms19092747.
2
Mimotope mimicking epidermal growth factor receptor alleviates mononuclear cell infiltration in exocrine glands induced by muscarinic acetylcholine 3 receptor.表皮生长因子受体模拟肽减轻毒蕈碱乙酰胆碱 3 受体诱导的外分泌腺单核细胞浸润
Clin Immunol. 2016 Feb;163:111-9. doi: 10.1016/j.clim.2016.01.006. Epub 2016 Jan 18.
3
Aquaporins in secretory glands and their role in Sjögren's syndrome.分泌腺中的水通道蛋白及其在干燥综合征中的作用。
Handb Exp Pharmacol. 2009(190):185-201. doi: 10.1007/978-3-540-79885-9_9.
4
Cutaneous and Mucosal Manifestations of Sjögren's Syndrome.干燥综合征的皮肤和黏膜表现。
Clin Rev Allergy Immunol. 2017 Dec;53(3):357-370. doi: 10.1007/s12016-017-8639-y.
5
Diffuse infiltrative lymphocytosis syndrome in children and adults infected with HIV-1: a model of rheumatic illness caused by acquired viral infection.感染HIV-1的儿童和成人中的弥漫性浸润性淋巴细胞增多综合征：一种由后天病毒感染引起的风湿性疾病模型。
Am J Reprod Immunol. 1992 Oct-Dec;28(3-4):247-50. doi: 10.1111/j.1600-0897.1992.tb00806.x.
6
Characteristics of Labial Gland Mesenchymal Stem Cells of Healthy Individuals and Patients with Sjögren's Syndrome: A Preliminary Study.健康个体与干燥综合征患者唇腺间充质干细胞的特征：一项初步研究。
Stem Cells Dev. 2017 Aug 15;26(16):1171-1185. doi: 10.1089/scd.2017.0045. Epub 2017 Jun 26.
7
8
The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review.弥漫浸润性淋巴细胞增多症（DILS）。全面综述。
J Autoimmun. 2015 May;59:19-25. doi: 10.1016/j.jaut.2015.01.010. Epub 2015 Feb 7.
9
Common T cell receptor clonotype in lacrimal glands and labial salivary glands from patients with Sjögren's syndrome.干燥综合征患者泪腺和唇腺中常见的T细胞受体克隆型
J Clin Invest. 1996 Apr 15;97(8):1969-77. doi: 10.1172/JCI118629.
10
Lacrimal and salivary gland inflammation in the C3H/Ipr autoimmune strain mouse: a potential mode for Sjögren's syndrome.C3H/Ipr自身免疫品系小鼠的泪腺和唾液腺炎症：干燥综合征的一种潜在模式。
Otolaryngol Head Neck Surg. 1992 Apr;106(4):394-9. doi: 10.1177/019459989210600413.
引用本文的文献
1
Xerostomia and associated factors among adults with HIV on HAART attending voluntary counseling and testing (VCT) clinics in Dar Es Salaam.达累斯萨拉姆接受自愿咨询检测（VCT）门诊治疗的接受高效抗逆转录病毒治疗（HAART）的成年HIV感染者的口干症及相关因素
BMC Oral Health. 2025 Apr 29;25(1):655. doi: 10.1186/s12903-025-05993-5.
2
Dry eye and systemic diseases.干眼与全身性疾病。
Saudi J Ophthalmol. 2025 Jan 2;39(1):5-13. doi: 10.4103/sjopt.sjopt_182_24. eCollection 2025 Jan-Mar.
3
A non-invasive model for diagnosis of primary Sjogren's disease based on salivary biomarkers, serum autoantibodies, and Schirmer's test.一种基于唾液生物标志物、血清自身抗体和施墨试验诊断原发性干燥综合征的非侵入性模型。
Arthritis Res Ther. 2024 Dec 19;26(1):217. doi: 10.1186/s13075-024-03459-7.
4
Enterovirus A71 infection-induced dry eye-like symptoms by damaging the lacrimal glands.肠道病毒 A71 感染通过破坏泪腺引发干眼症样症状。
Front Cell Infect Microbiol. 2024 Apr 2;14:1340075. doi: 10.3389/fcimb.2024.1340075. eCollection 2024.
5
Evaluation of tear film in patients with AIDS without opportunistic ocular infections in the era of COVID-19: A case-control study.COVID-19时代无机会性眼部感染的艾滋病患者泪膜评估：一项病例对照研究。
Indian J Ophthalmol. 2024 May 1;72(Suppl 3):S409-S414. doi: 10.4103/IJO.IJO_1636_23. Epub 2024 Feb 5.
6
Current developments and opportunities of pluripotent stem cells-based therapies for salivary gland hypofunction.基于多能干细胞的唾液腺功能减退治疗的当前进展与机遇
Front Cell Dev Biol. 2024 Jan 19;12:1346996. doi: 10.3389/fcell.2024.1346996. eCollection 2024.
7
Salivary biochemical parameters in people living with HIV on ART and dental caries: a cross-sectional study in Monastir, Tunisia.ART 治疗下的 HIV 感染者的唾液生化参数与龋齿：突尼斯莫纳斯提尔的一项横断面研究。
BMC Oral Health. 2024 Jan 6;24(1):35. doi: 10.1186/s12903-023-03821-2.
8
Dry eye disease caused by viral infection: Past, present and future.病毒性感染导致的干眼疾病：过去、现在和未来。
Virulence. 2024 Dec;15(1):2289779. doi: 10.1080/21505594.2023.2289779. Epub 2023 Dec 4.
9
Oral Health Outcomes In An HIV Cohort With Comorbidities- Implementation Roadmap For A Longitudinal Prospective Observational Study.合并症HIV队列中的口腔健康结局——一项纵向前瞻性观察研究的实施路线图
Res Sq. 2023 Oct 4:rs.3.rs-3390162. doi: 10.21203/rs.3.rs-3390162/v1.
10
Current oral hygiene and recreational behavioral trends in HIV disease.目前 HIV 疾病中的口腔卫生和娱乐行为趋势。
Clin Exp Dent Res. 2023 Aug;9(4):721-732. doi: 10.1002/cre2.762. Epub 2023 Jul 4.
本文引用的文献
1
Risk of Diffuse Infiltrative Lymphocytosis Syndrome in HIV-Infected Patients: A Nationwide Population-Based Cohort Study.HIV 感染者弥漫性浸润性淋巴细胞增多综合征的风险：一项全国范围内基于人群的队列研究。
J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):158-163. doi: 10.1097/QAI.0000000000001802.
2
Anterior segment and external ocular disorders associated with HIV infections in the era of HAART in Chiang Mai University Hospital, a prospective descriptive cross sectional study.清迈大学医院抗逆转录病毒治疗时代与 HIV 感染相关的前节和眼外疾病：一项前瞻性描述性横断面研究。
PLoS One. 2018 Feb 21;13(2):e0193161. doi: 10.1371/journal.pone.0193161. eCollection 2018.
3
Serum components and clinical efficacies of autologous serum eye drops in dry eye patients with active and inactive Sjogren syndrome.自体血清滴眼液对伴有活动期和非活动期干燥综合征的干眼患者的血清成分及临床疗效
Taiwan J Ophthalmol. 2017 Oct-Dec;7(4):213-220. doi: 10.4103/tjo.tjo_102_17.
4
The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research.干眼症的病理生理学：我们所了解的情况及未来研究方向
Ophthalmology. 2017 Nov;124(11S):S4-S13. doi: 10.1016/j.ophtha.2017.07.010.
5
HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining.经HIV-1 p24抗原免疫染色确诊的腮腺HIV相关性良性淋巴上皮囊肿
BMJ Case Rep. 2017 Sep 28;2017:bcr-2017-221869. doi: 10.1136/bcr-2017-221869.
6
Human immunodeficiency virus-associated cystic lymphoid hyperplasia: An immunohistochemical description.人类免疫缺陷病毒相关的囊性淋巴样增生：免疫组织化学描述。
Indian J Pathol Microbiol. 2017 Jul-Sep;60(3):336-340. doi: 10.4103/IJPM.IJPM_664_16.
7
Treatment of Dry Eye Disease with Autologous Platelet-Rich Plasma: A Prospective, Interventional, Non-Randomized Study.自体富血小板血浆治疗干眼疾病：一项前瞻性、干预性、非随机研究。
Ophthalmol Ther. 2017 Dec;6(2):285-293. doi: 10.1007/s40123-017-0100-z. Epub 2017 Aug 8.
8
Lacrimal gland development: From signaling interactions to regenerative medicine.泪腺发育：从信号相互作用到再生医学。
Dev Dyn. 2017 Dec;246(12):970-980. doi: 10.1002/dvdy.24551. Epub 2017 Aug 18.
9
CROI 2017: Advances in Antiretroviral Therapy.2017年逆转录病毒与机会性感染会议：抗逆转录病毒疗法的进展
Top Antivir Med. 2017 May/Jun;25(2):51-67.
10
HIV-infected individuals on long-term antiretroviral therapy are at higher risk for ocular disease.接受长期抗逆转录病毒治疗的艾滋病毒感染者患眼部疾病的风险更高。
Epidemiol Infect. 2017 Sep;145(12):2520-2529. doi: 10.1017/S0950268817000978. Epub 2017 May 19.
Zotero 插件