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脑瘫的临床表现、相关疾病及病因学因素:一项基于荷兰人群的研究。

Clinical presentation, associated disorders and aetiological moments in Cerebral Palsy: a Dutch population-based study.

作者信息

Wichers M J, Odding E, Stam H J, van Nieuwenhuizen O

机构信息

Department of Child Rehabilitation, Leijpark Rehabilitation Centre, Tilburg, The Netherlands.

出版信息

Disabil Rehabil. 2005 May 20;27(10):583-9. doi: 10.1080/09638280400018445.

DOI:10.1080/09638280400018445
PMID:16019867
Abstract

PURPOSE

Cerebral Palsy (CP) contains varying clinical presentations, associated disorders and aetiological moments. Quantitative data and trends on these aspects were lacking in The Netherlands.

METHOD

Within a population-based study on prevalence, presentation and functioning of Dutch children with CP born in the years 1977-1988, individual history taking, examination and medical file checking was done by experienced clinicians. Clinical subtypes, motor disability, important co-morbidity (mental retardation, visual disability and epilepsy) were recorded, aetiological moments identified if possible. By comparing the four most recent years with the earlier years possible trends were studied.

RESULTS

A quarter of children beforehand recorded as CP did not meet inclusion criteria after individual examination. Spastic subtypes accounted for over 90% of all CP cases: bilateral spastic cerebral palsy as a group are the majority although spastic hemiplegia is percentage-wise the largest individual clinical subtype. Epilepsy and mental retardation are common. Clinical patterns and associated disorders remained rather constant comparing earlier to more recent birth years.

CONCLUSIONS

An early diagnosis of CP may be challenged. General clinical patterns remained rather constant in following years, as did most studied items. Even if this study revealed a prevalence rise, no aspect stood out as a possible explanation for this prevalence rise. Comparable studies performed elsewhere showed similar findings.

摘要

目的

脑瘫(CP)具有不同的临床表现、相关疾病和病因。荷兰缺乏关于这些方面的定量数据和趋势。

方法

在一项基于人群的关于1977 - 1988年出生的荷兰脑瘫儿童患病率、表现和功能的研究中,由经验丰富的临床医生进行个人病史采集、检查和病历核查。记录临床亚型、运动残疾、重要的合并症(智力障碍、视力残疾和癫痫),尽可能确定病因。通过比较最近四年和早期年份来研究可能的趋势。

结果

在个体检查后,四分之一之前记录为脑瘫的儿童不符合纳入标准。痉挛型亚型占所有脑瘫病例的90%以上:尽管痉挛性偏瘫在百分比上是最大的个体临床亚型,但双侧痉挛性脑瘫作为一个群体占多数。癫痫和智力障碍很常见。与早期出生年份相比,临床模式和相关疾病在最近出生年份保持相当稳定。

结论

脑瘫的早期诊断可能面临挑战。在随后的几年中,一般临床模式以及大多数研究项目都保持相当稳定。即使这项研究显示患病率有所上升,但没有任何方面能突出作为患病率上升的可能解释。其他地方进行的类似研究也显示了类似的结果。

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