Dörr W, Schlichting S, Bray M A, Flockhart I R, Hopewell J W
Radiobiology Laboratory, Department of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany.
Int J Radiat Biol. 2005 Mar;81(3):243-50. doi: 10.1080/09553000500103033.
To define the effect of dexpanthenol with or without Aloe vera extract on radiation-induced oral mucositis.
Mouse tongue mucosal ulceration was analysed as the clinically relevant endpoint. Graded single or fractionated dose irradiation (10 x 3 Gy/2 weeks, graded test doses on day 14) were combined with topical administration of dexpanthenol or a base, with or without Aloe vera extract. The formulations were applied for 14 days (single dose) or 24 days after the first fraction.
Single dose irradiation resulted in an ED50 (dose at which a positive mucosal response was expected in 50% of the animals irradiated) of 11.9+/-1.2 Gy. None of the formulations yielded a significant change in incidence or time course of ulceration. Test irradiation after 10 x 3 Gy gave an ED50 of 9.0+/-0.1 Gy. Base treatment increased the ED50-values to 10.5+/-0.8 Gy (p = 0.0095) and 9.9+/-0.7 Gy (p = 0.0445) without or with Aloe vera. Dexpanthenol resulted in ED50 values of 9.5+/-0.1 Gy without Aloe vera (p > 0.05), and of 10.9+/-0.9 Gy (p = 0.0035) with Aloe vera. The latent time to ulceration was prolonged, compared to the control (6.3 days) without Aloe vera (8.0-8.2 days, p < 0.001) and with dexpanthenol and Aloe vera (7.3 days, p = 0.0239).
With single dose irradiation, neither dexpanthenol nor Aloe vera extract significantly changed the oral mucosal radiation response. With fractionated irradiation, drug administration significantly increased the isoeffective radiation doses, independent of dexpanthenol or Aloe vera content. Neither dexpanthenol nor Aloe vera display a prophylactic potential.
确定泛醇单独或与芦荟提取物联合使用对放射性口腔黏膜炎的影响。
将小鼠舌黏膜溃疡作为临床相关终点进行分析。分级单次或分次剂量照射（10×3 Gy/2周，第14天给予分级测试剂量）与局部应用泛醇或基质联合使用，其中基质添加或不添加芦荟提取物。制剂应用14天（单次剂量）或在首次分次照射后应用24天。
单次剂量照射导致半数有效剂量（ED50，即预期在50%受照射动物中出现阳性黏膜反应的剂量）为11.9±1.2 Gy。没有一种制剂使溃疡的发生率或时间进程发生显著变化。10×3 Gy照射后的测试照射得出ED50为9.0±0.1 Gy。基质治疗在不添加或添加芦荟的情况下分别将ED50值提高到10.5±0.8 Gy（p = 0.0095）和9.9±0.7 Gy（p = 0.0445）。泛醇在不添加芦荟时得出的ED50值为9.5±0.1 Gy（p > 0.05），添加芦荟时为10.9±0.9 Gy（p = 0.0035）。与不添加芦荟的对照组（6.3天）相比，溃疡的潜伏期延长，不添加芦荟时为8.0 - 8.2天（p < 0.001），添加泛醇和芦荟时为7.3天（p = 0.0239）。
单次剂量照射时，泛醇和芦荟提取物均未显著改变口腔黏膜的放射反应。分次照射时，药物给药显著提高了等效有效放射剂量，与泛醇或芦荟含量无关。泛醇和芦荟均未显示出预防潜力。
