Abi-Saab Danielle, Beauvais John, Mehm John, Brody Michelle, Gottschalk Christopher, Kosten Thomas R
Yale University School of Medicine, VA Connecticut Healthcare System, Department of Psychiatry, West Haven, Connecticut 06516, USA.
Am J Addict. 2005 Mar-Apr;14(2):166-78. doi: 10.1080/10550490590924854.
Neuropsychological deficits in the areas of learning, memory, attention, and abstraction abilities have been associated with cocaine dependence, especially during the period of early abstinence. Although cocaine users tend to be multidrug users, few studies have focused on the combined effect of alcohol and cocaine on neuropsychological functioning. Consistent with prior research, results from the current study indicated that cocaine-dependent subjects showed a significantly greater degree of neuropsychological impairment as compared to controls. In addition, cocaine-dependent subjects with a history of alcohol disorder showed less memory impairment but similar impairments in attention and overall neuropsychological functioning as cocaine subjects with no such history. The vasodilatation produced by alcohol may attenuate some of the vasoconstriction and neurotoxic effects of cocaine, accounting for the fewer deficits in this group.
学习、记忆、注意力和抽象能力等方面的神经心理学缺陷与可卡因成瘾有关，尤其是在早期戒断期间。尽管可卡因使用者往往同时使用多种药物，但很少有研究关注酒精和可卡因对神经心理功能的综合影响。与先前的研究一致，当前研究结果表明，与对照组相比，可卡因成瘾者的神经心理学损伤程度明显更高。此外，有酒精障碍病史的可卡因成瘾者的记忆损伤较少，但在注意力和整体神经心理功能方面的损伤与无此类病史的可卡因使用者相似。酒精产生的血管舒张作用可能会减轻可卡因的一些血管收缩和神经毒性作用，这解释了该组中缺陷较少的原因。
