Kumar Pankaj, Khanna Madhu, Srivastava Vikram, Tyagi Yogesh Kumar, Raj Hanumanthrao G, Ravi K
Department of Respiratory Virology, VP Chest Institute, University of Delhi, Delhi 110-007, India.
Exp Lung Res. 2005 Jun;31(5):449-59. doi: 10.1080/019021490927088.
In the mice, instillation of influenza virus A/Udorn/317/72(H3N2) intranasally resulted in a significant decrease in the pulmonary concentrations of catalase, reduced glutathione, and superoxide dismutase. There was a decrease in vitamin E level also. These effects were observed on the 5th day after viral instillation. Oral supplementation with quercetin simultaneous with viral instillation produced significant increases in the pulmonary concentrations of catalase, reduced glutathione, and superoxide dismutase. However, quercetin did not reverse the fall in vitamin E level associated with the viral infection. It is concluded that during influenza virus infection, there is "oxidative stress." Because quercetin restored the concentrations of many antioxidants, it is proposed that it may be useful as a drug in protecting the lung from the deleterious effects of oxygen derived free radicals released during influenza virus infection.
在小鼠中，经鼻内滴注甲型流感病毒A/Udorn/317/72（H3N2）后，过氧化氢酶、还原型谷胱甘肽和超氧化物歧化酶的肺内浓度显著降低。维生素E水平也有所下降。这些效应在病毒滴注后第5天观察到。在病毒滴注的同时口服槲皮素补充剂，可使过氧化氢酶、还原型谷胱甘肽和超氧化物歧化酶的肺内浓度显著升高。然而，槲皮素并未逆转与病毒感染相关的维生素E水平下降。结论是，在流感病毒感染期间存在“氧化应激”。由于槲皮素恢复了多种抗氧化剂的浓度，因此建议它可能作为一种药物，用于保护肺部免受流感病毒感染期间释放的氧衍生自由基的有害影响。
