Morimoto Ryosuke, Isegawa Yuji
Department of Health and Nutrition, Faculty of Human Life Science, Shikoku University, Tokushima 771-1192, Japan.
Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University, Sakai, Osaka 599-8531, Japan.
Foods. 2023 Oct 22;12(20):3866. doi: 10.3390/foods12203866.
Influenza is an acute respiratory illness caused by the influenza virus, in response to which vaccines and antiviral drugs are administered. In recent years, the antiviral effects of plants and foods have garnered attention. This review is the first to summarize the therapeutic properties of wild watermelon ( var. against influenza from a phytochemical viewpoint. Wild watermelon is a wild plant with significant potential as a therapeutic candidate in antiviral strategies, when focused on its multiple anti-influenza functionalities. Wild watermelon juice inhibits viral growth, entry, and replication. Hence, we highlight the possibility of utilizing wild watermelon for the prevention and treatment of influenza with stronger antiviral activity. Phytochemicals and phytoestrogen (polyphenol, flavonoids, and prenylated compounds) in wild watermelon juice contribute to this activity and inhibit various stages of viral replication, depending on the molecular structure. Wild plants and foods closely related to the original species contain many natural compounds such as phytochemicals, and exhibit various viral growth inhibitory effects. These natural products provide useful information for future antiviral strategies.
流感是一种由流感病毒引起的急性呼吸道疾病，针对此会使用疫苗和抗病毒药物。近年来，植物和食物的抗病毒作用受到了关注。本综述首次从植物化学角度总结了野生西瓜（变种）对流感的治疗特性。野生西瓜是一种野生植物，当其多种抗流感功能受到关注时，它在抗病毒策略中作为治疗候选物具有巨大潜力。野生西瓜汁可抑制病毒生长、进入和复制。因此，我们强调了利用野生西瓜预防和治疗流感的可能性，其具有更强的抗病毒活性。野生西瓜汁中的植物化学物质和植物雌激素（多酚、黄酮类化合物和异戊烯化化合物）促成了这种活性，并根据分子结构抑制病毒复制的各个阶段。与原始物种密切相关的野生植物和食物含有许多天然化合物，如植物化学物质，并表现出各种病毒生长抑制作用。这些天然产物为未来的抗病毒策略提供了有用信息。
