Born Christoph, Dittmann Sandra, Post Robert M, Grunze Heinz
Psychiatrische Klinik der LMU, München.
Arch Suicide Res. 2005;9(3):301-6. doi: 10.1080/13811110590929541.
Different from lithium, there is little known so far on the effect of (newer) anticonvulsants on suicidality in bipolar patients. We evaluated data of 128 patients with bipolar disorders for suicidal ideation. These patients were treated with various mood-stabilizing medications for at least 3 months. No suicide attempt or completed suicide occurred in this cohort during prospective follow up for an average of 13.3 +/- 12.1 years. Compared to lithium, the relative risk of suicidal ideation was numerically slightly higher for valproate, carbamazepine and a small group treated with either levetiracetam, oxcarbazepine or topiramate, but lower in patients treated with lamotrigine, without reaching statistical significance. Confounding variables in more intensive care of these patients participating in a naturalistic study may blur small differences and contribute to a generally favorable outcome.
与锂不同，目前对于（新型）抗惊厥药物对双相情感障碍患者自杀倾向的影响知之甚少。我们评估了128例双相情感障碍患者的自杀意念数据。这些患者接受了各种心境稳定剂治疗至少3个月。在平均13.3±12.1年的前瞻性随访期间，该队列中未发生自杀未遂或自杀死亡事件。与锂相比，丙戊酸盐、卡马西平和一小部分接受左乙拉西坦、奥卡西平或托吡酯治疗的患者自杀意念的相对风险在数值上略高，但接受拉莫三嗪治疗的患者自杀意念相对风险较低，不过均未达到统计学显著性。参与一项自然主义研究的这些患者在更强化治疗中的混杂变量可能会掩盖微小差异，并导致总体上良好的结果。
