Morvai Veronika, Szakmáry Eva, Ungváry György
Department of Occupational and Environmental Health, Semmelweis University, Medical Faculty, Budapest, Hungary.
J Toxicol Environ Health A. 2005 May 28;68(10):797-809. doi: 10.1080/15287390590930144.
Carbon disulfide exerted adverse effects on the structure or hemodynamics of the cardiovascular system, and whether ethanol exposure modifies the cardiovascular effect of carbon disulfide, was examined. Male Sprague-Dawley rats were used in the study. Animals in the control and ethanol groups drank water containing 5% sugar, or 10% ethanol in addition to 5% sugar, respectively, for 14 wk. Sepatare animals inhaled 700 mg/m3 of carbon disulfide for 6 h daily. Carbon disulfide treatment did not affect the food and fluid consumption of the animals, while this gas decreased body mass gain. CS2 increased arterial blood pressure and cardiac index, decreased their cardiac output, the fraction of the cardiac output, and blood flow for the kidneys and the lungs, and increased the relative heart, liver, and kidneys mass and the vascular resistance of the brain, lungs, and kidneys. Ethanol decreased the food and fluid consumption and body mass gain of the animals, the fraction of the cardiac output for the kidneys, and the vascular resistance of the liver, while it increased the blood flow of the brain and liver. Simultaneous administration of carbon disulfide and ethanol decreased the heart rate and increased the QRS duration. Significant interaction was found between the effect in case of heart rate, PQ distance, and QRS duration; carbon disulfide significantly increased the minimal-moderate effect of ethanol on all three parameters. With histological examinations no pathologic alterations were found in the organs studied. It was concluded that the early hemodynamic changes produced by carbon disulfide may play a significant role in the pathomechanism of the effects of the substance (hypertension, damage to the myocardium and kidneys). On the other hand, a potentiating interaction of carbon disulfide was expected with the effects of ethanol, at the administered concentration and dose in the study.
二硫化碳对心血管系统的结构或血流动力学产生了不良影响，本研究考察了乙醇暴露是否会改变二硫化碳对心血管系统的影响。研究中使用了雄性斯普拉格-道利大鼠。对照组和乙醇组的动物分别饮用含5%蔗糖的水，或除5%蔗糖外还含有10%乙醇的水，持续14周。另外，动物每天吸入700mg/m³的二硫化碳，持续6小时。二硫化碳处理不影响动物的食物和液体摄入量，但这种气体减少了体重增加。二硫化碳升高了动脉血压和心脏指数，降低了心输出量、心输出量分数以及肾脏和肺部的血流量，并增加了心脏、肝脏和肾脏的相对重量以及脑、肺和肾脏的血管阻力。乙醇减少了动物的食物和液体摄入量以及体重增加、肾脏的心输出量分数和肝脏的血管阻力，同时增加了脑和肝脏的血流量。同时给予二硫化碳和乙醇可降低心率并延长QRS波时限。在心率、PQ间期和QRS波时限方面发现了显著的交互作用；二硫化碳显著增强了乙醇对所有这三个参数的最小至中等程度的影响。组织学检查未发现所研究器官有病理改变。研究得出结论，二硫化碳引起的早期血流动力学变化可能在该物质作用的病理机制（高血压、心肌和肾脏损伤）中起重要作用。另一方面，在本研究给予的浓度和剂量下，预计二硫化碳与乙醇的作用会有增强性相互作用。
