Neale Jennifer C C, Schmelzer Kara R, Gulland Frances M D, Berg Elizabeth A, Tjeerdema Ronald S
Department of Environmental Toxicology, University of California at Davis, Davis, California 95616, USA.
J Toxicol Environ Health A. 2005 May 14;68(9):687-91. doi: 10.1080/15287390590925429.
Maternal transfer of persistent marine contaminants to offspring via milk has been documented in marine mammals, but temporal dynamics of this phenomenon throughout the lactation period are poorly understood. Exposures to organohalogens were investigated in harbor seal pups admitted to a rehabilitation center in north central California during the lactation periods of 2001 and 2002. Ten congeners of PCBs, three congeners of PBDEs, and p,p'-DDE were quantified in whole blood samples. Levels of contaminants increased with admit date, assumed to correlate positively with pup age. This trend was significant when latitude of stranding site, body condition, and body length were included as variables in the model. Contaminant-admit date relationships appeared nonlinear (i.e., threshold or exponential), with greatest increases in contaminant concentrations during late lactation.
海洋哺乳动物中，母体通过乳汁将持久性海洋污染物传递给后代的现象已有记录，但对于这一现象在整个哺乳期的时间动态变化却知之甚少。在2001年和2002年哺乳期，对加利福尼亚州中北部一家康复中心收治的港海豹幼崽进行了有机卤素暴露情况调查。对全血样本中的10种多氯联苯同系物、3种多溴二苯醚同系物和p,p'-滴滴涕进行了定量分析。污染物水平随入院日期增加，假定与幼崽年龄呈正相关。当将搁浅地点的纬度、身体状况和体长作为变量纳入模型时，这一趋势具有显著性。污染物-入院日期关系呈现非线性（即阈值或指数关系），在哺乳期后期污染物浓度增加最为显著。
