Karaharju-Suvanto T, Peltonen J, Kahri A, Karaharju E O
Department of Paedodontics, University of Helsinki, Finland.
Int J Oral Maxillofac Surg. 1992 Apr;21(2):118-21. doi: 10.1016/s0901-5027(05)80547-8.
Distraction bone healing has been studied in long bones but there are only few experiments reported in relation to the mandible. The histological pattern of the healing process after mandibular distraction is described. After osteotomy the mandibles of 17 growing sheep were lengthened by gradual distraction using an external fixation device. The follow-up varied from 0 to 52 weeks. The results indicate that bone healing in mandibles is principally the same as in long bones. Four phases can be observed during the repair process: 1) formation of collagen aligned in the direction of distraction, 2) bone formation over the collagen template, 3) bone union across the distraction gap, and 4) remodelling of the lengthened segment. Some increased osteoblast activity was also seen in the control side.
牵张成骨已在长骨中得到研究，但关于下颌骨的相关实验报道较少。本文描述了下颌骨牵张后愈合过程的组织学模式。对17只生长中的绵羊的下颌骨进行截骨后，使用外固定装置逐渐牵张延长。随访时间为0至52周。结果表明，下颌骨的骨愈合过程与长骨基本相同。在修复过程中可观察到四个阶段：1）沿牵张方向排列的胶原形成；2）胶原模板上的骨形成；3）牵张间隙处的骨愈合；4）延长节段的重塑。在对照侧也观察到一些成骨细胞活性增加的情况。
