细胞质凹陷对植入结果有负面影响。
Cytoplasmic pitting has a negative influence on implantation outcome.
作者信息
Ebner Thomas, Tews Gernot, Sommergruber Michael, Moser Marianne
机构信息
Women's General Hospital, IVF-Unit, Lederergasse 47, A-4020 Linz, Upper Austria, Austria.
出版信息
J Assist Reprod Genet. 2005 Jun;22(6):239-44. doi: 10.1007/s10815-005-5146-5.
PURPOSE
Since cytoplasmic pitting is a morphological phenomenon discussed controversially, this study was set up in order to assess the actual influence of cytoplasmic pitting on treatment outcome.
METHODS
Four hundred and one patients undergoing 484 consecutive treatment cycles were evaluated retrospectively in order to assess the actual influence of pitting on treatment outcome.
RESULTS
Pitting was found to be reduced in single culture as compared to group culture (p < 0.01). No correlation of cytoplasmic texture with rates of implantation and pregnancy could be observed, but a significantly higher proportion (p < 0.05) of gestational sacs vanished in the group with exclusive transfer of pitted embryos compared to the unaffected group. Obstetric and perinatal outcome was not affected.
CONCLUSIONS
It is possible that culture conditions favor cytoplasmic pitting, a morphological phenomenon which, in the extreme case, may result in early loss of gestation sacs.
目的
由于细胞质凹陷是一种存在争议的形态学现象，开展本研究以评估细胞质凹陷对治疗结局的实际影响。
方法
回顾性评估401例接受484个连续治疗周期的患者，以评估凹陷对治疗结局的实际影响。
结果
与群体培养相比，单培养中发现凹陷减少（p < 0.01）。未观察到细胞质质地与着床率和妊娠率之间存在相关性，但与未受影响的组相比，仅移植有凹陷胚胎的组中妊娠囊消失的比例显著更高（p < 0.05）。产科和围产期结局未受影响。
结论
培养条件可能有利于细胞质凹陷，这种形态学现象在极端情况下可能导致妊娠囊早期丢失。
Zotero 插件