子宫内膜异位症患者与输卵管因素不孕症患者体外受精的结局比较。
Outcome of IVF in patients with endometriosis in comparison with tubal-factor infertility.
作者信息
Bergendal A, Naffah S, Nagy C, Bergqvist A, Sjöblom P, Hillensjö T
机构信息
Karolinska Institutet, Huddinge University Hospital, Sweden.
出版信息
J Assist Reprod Genet. 1998 Oct;15(9):530-4. doi: 10.1023/a:1022526002421.
Abstract
PURPOSE
The aim of this retrospective study was to compare the outcome of in vitro fertilization and embryo transfer in women with endometriosis and a control group with tubal-factor infertility.
METHODS
Forty-eight patients with endometriosis underwent 65 cycles of in vitro fertilization and embryo transfer at Huddinge University Hospital. The matched control group with tubal-factor infertility consisted of 98 cycles in 98 patients. These groups were retrospectively analyzed regarding stimulation, fertilization, embryo development, implantation, and pregnancy outcome.
RESULTS
The fertilization rate was significantly lower in women with endometriosis, but the cleavage, implantation, and pregnancy rates did not differ.
CONCLUSIONS
Our results show that women with endometriosis have a lower fertilization rate compared with women with tubal-factor infertility. However, once the oocyte is fertilized, it seems that the preembryo has a normal chance of implantation, leading to similar pregnancy rates.
摘要
目的
本回顾性研究的目的是比较子宫内膜异位症患者与输卵管因素不孕对照组在体外受精和胚胎移植方面的结果。
方法
48例子宫内膜异位症患者在胡丁厄大学医院接受了65个周期的体外受精和胚胎移植。输卵管因素不孕的匹配对照组由98例患者的98个周期组成。对这些组在刺激、受精、胚胎发育、着床和妊娠结局方面进行回顾性分析。
结果
子宫内膜异位症女性的受精率显著较低，但分裂、着床和妊娠率没有差异。
结论
我们的结果表明，与输卵管因素不孕的女性相比，子宫内膜异位症女性的受精率较低。然而，一旦卵母细胞受精，似乎胚胎前期有正常的着床机会，导致相似的妊娠率。
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本文引用的文献
1
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Hum Reprod. 1996 Oct;11(10):2269-75. doi: 10.1093/oxfordjournals.humrep.a019088.
2
The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program.子宫内膜异位症对胚胎着床的影响：来自耶鲁大学体外受精与胚胎移植项目的结果。
Fertil Steril. 1996 Mar;65(3):603-7. doi: 10.1016/s0015-0282(16)58162-x.
3
The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro.子宫内膜异位症患者腹腔液对人精子体外功能的影响。
Am J Obstet Gynecol. 1996 Jun;174(6):1779-83; discussion 1783-5. doi: 10.1016/s0002-9378(96)70210-7.
4
Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis.子宫内膜异位症女性腹膜巨噬细胞细胞因子的基础分泌和刺激分泌
Fertil Steril. 1996 May;65(5):925-30.
5
Effect of peritoneal fluid from infertile women with endometriosis on ionophore-stimulated acrosome loss.
Hum Reprod. 1995 Sep;10(9):2419-22. doi: 10.1093/oxfordjournals.humrep.a136310.
6
Immunological aspects of endometriosis.
Int J Gynaecol Obstet. 1995 Sep;50 Suppl 1:S3-10. doi: 10.1016/0020-7292(95)02508-a.
7
Can staging systems for endometriosis based on anatomic location and lesion type predict pregnancy rates?基于解剖位置和病变类型的子宫内膜异位症分期系统能否预测妊娠率？
Int J Fertil Menopausal Stud. 1993 Jul-Aug;38(4):241-9.
8
Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation.子宫内膜异位症患者辅助生殖的结局：体外受精和卵母细胞捐赠的结果
Hum Reprod. 1994 Apr;9(4):725-9. doi: 10.1093/oxfordjournals.humrep.a138578.
9
Endometriosis and infertility: raised iron concentration in the peritoneal fluid and its effect on the acrosome reaction.
Hum Reprod. 1994 Jun;9(6):1153-7. doi: 10.1093/oxfordjournals.humrep.a138649.
10
Increased incidence of aberrant morphological phenotypes in human embryogenesis--an association with endometriosis.
J Assist Reprod Genet. 1995 Feb;12(2):106-12. doi: 10.1007/BF02211378.
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