Bergendal A, Naffah S, Nagy C, Bergqvist A, Sjöblom P, Hillensjö T
Karolinska Institutet, Huddinge University Hospital, Sweden.
J Assist Reprod Genet. 1998 Oct;15(9):530-4. doi: 10.1023/a:1022526002421.
The aim of this retrospective study was to compare the outcome of in vitro fertilization and embryo transfer in women with endometriosis and a control group with tubal-factor infertility.
Forty-eight patients with endometriosis underwent 65 cycles of in vitro fertilization and embryo transfer at Huddinge University Hospital. The matched control group with tubal-factor infertility consisted of 98 cycles in 98 patients. These groups were retrospectively analyzed regarding stimulation, fertilization, embryo development, implantation, and pregnancy outcome.
The fertilization rate was significantly lower in women with endometriosis, but the cleavage, implantation, and pregnancy rates did not differ.
Our results show that women with endometriosis have a lower fertilization rate compared with women with tubal-factor infertility. However, once the oocyte is fertilized, it seems that the preembryo has a normal chance of implantation, leading to similar pregnancy rates.
本回顾性研究的目的是比较子宫内膜异位症患者与输卵管因素不孕对照组在体外受精和胚胎移植方面的结果。
48例子宫内膜异位症患者在胡丁厄大学医院接受了65个周期的体外受精和胚胎移植。输卵管因素不孕的匹配对照组由98例患者的98个周期组成。对这些组在刺激、受精、胚胎发育、着床和妊娠结局方面进行回顾性分析。
子宫内膜异位症女性的受精率显著较低，但分裂、着床和妊娠率没有差异。
我们的结果表明，与输卵管因素不孕的女性相比，子宫内膜异位症女性的受精率较低。然而，一旦卵母细胞受精，似乎胚胎前期有正常的着床机会，导致相似的妊娠率。
