低促性腺激素性性腺功能减退女性在体外受精-胚胎移植项目中的生殖表现。
The reproductive performance of women with hypogonadotropic hypogonadism in an in vitro fertilization and embryo transfer program.
作者信息
Ulug Ulun, Ben-Shlomo Izhar, Tosun Süleyman, Erden Halit Firat, Akman Mehmet Ali, Bahceci Mustafa
机构信息
Bahceci Women Health Care Center and German Hospital, Istanbul, Turkey.
出版信息
J Assist Reprod Genet. 2005 Apr;22(4):167-71. doi: 10.1007/s10815-005-4914-6.
PURPOSE
To evaluate the outcome of women with hypogonadotropic hypogonadism undergoing in-vitro fertilization (IVF).
METHODS
We retrospectively assessed outcomes in 58 women with hypogonadotropic hypogonadism (HH) and, as matched controls, in 116 women with tubal factor (TF) infertility who underwent assisted reproduction treatment (ART). For ovulation induction, human menopausal gonadotropin (hMG) was used in HH patients and a combination of hMG and gonadotropin releasing hormone (GnRH) agonist was used in TF patients. Conception and implantation rates, as well as duration of stimulation and number of oocytes retrieved, were the main outcome measures.
RESULTS
Of the 58 HH patients, 53 (91.3%) responded adequately to ovulation induction and underwent ET. A larger amount of gonadotropins and a longer duration of ovarian stimulation were needed in HH patients than in TF patients. The mean number of retrieved oocytes and implantation rates did not differ between the groups. In addition, there were no differences between the HH and TF groups in pregnancy (53.8 vs. 48.6%) and multiple pregnancy (63.4 vs. 48.4%) rates. In the HH group, the miscarriage rate was 3.4%, and none of these patients developed severe OHSS.
CONCLUSION
IVF in HH patients, in which there was a background of previous failed ovulation induction, was as successful as in women with TF infertility.
目的
评估接受体外受精（IVF）的低促性腺激素性性腺功能减退女性的治疗结果。
方法
我们回顾性评估了58例低促性腺激素性性腺功能减退（HH）女性以及116例输卵管因素（TF）不孕女性作为匹配对照的治疗结果，这些女性均接受了辅助生殖治疗（ART）。在促排卵过程中，HH患者使用人绝经期促性腺激素（hMG），TF患者使用hMG和促性腺激素释放激素（GnRH）激动剂联合用药。主要观察指标为受孕率、着床率、刺激持续时间和获卵数。
结果
58例HH患者中，53例（91.3%）对促排卵有充分反应并接受了胚胎移植（ET）。HH患者比TF患者需要更多的促性腺激素和更长的卵巢刺激时间。两组间的平均获卵数和着床率无差异。此外，HH组和TF组在妊娠率（53.8%对48.6%）和多胎妊娠率（63.4%对48.4%）方面也无差异。在HH组中，流产率为3.4%，且这些患者均未发生严重的卵巢过度刺激综合征（OHSS）。
结论
对于既往促排卵失败的HH患者，IVF治疗与TF不孕女性一样成功。
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