Złotkowska Renata
Zakład Epidemiologii, Instytut Medycyny Pracy i Zdrowia Srodowiskowego w Sosnowcu.
Pneumonol Alergol Pol. 2004;72(9-10):400-2.
The aim of the study was to evaluate whether significant bronchial constriction which is consequence of histamine administration during the bronchial challenge is accompanied by drop in oxygen saturation in blood (SaO2). A practical aim was to answer the question whether monitoring of saturation by pulsoximetry during the bronchial challenge could improve its method. A study was performed in a group of 25 females and males with non-specific bronchial hyperreactivity. Results of this study revealed a statistically significant association between drop in FEV1 caused by administration of histamine and drop in oxygen saturation, and no association between drop in MEF50 and drop in SaO2. Drop in saturation in blood was not high which does not justify supplementary using of pulsoximetry during the bronchial challenge test.
该研究的目的是评估在支气管激发试验期间因注射组胺而导致的显著支气管收缩是否会伴有血液中氧饱和度（SaO2）下降。一个实际目的是回答在支气管激发试验期间通过脉搏血氧饱和度测定法监测饱和度是否能改进该方法这一问题。对一组25名具有非特异性支气管高反应性的女性和男性进行了一项研究。该研究结果显示，注射组胺引起的第一秒用力呼气量（FEV1）下降与氧饱和度下降之间存在统计学上的显著关联，而最大呼气中期流速50%（MEF50）下降与SaO2下降之间无关联。血液中饱和度的下降幅度不大，这表明在支气管激发试验期间没有理由额外使用脉搏血氧饱和度测定法。
