Schultebraucks R, Frank W, Loddenkemper R
Lungenklinik Heckeshorn, Krankenhaus Zehlendorf, Berlin.
Pneumologie. 1990 Feb;44 Suppl 1:362-3.
In 37 patients with clinically suspected non-specific bronchial hyperreactivity, a comparative study was performed prior to and following bronchial challenge with histamine employing the following parameters: flow-volume curve, whole-body plethysmography, single-breath spirometry, capillary blood gas analysis. Four types of reaction can be distinguished: isolated bronchial reaction, isolated gas transfer disturbance, dual reaction, no reaction. A Correlation of the induced gas transfer disturbance was found only for the flow data reflecting small airways dysfunction (Vmax 25%), but not for the basic lung function parameters. The transfer factor and transfer coefficient are insensitive and, on average, show only small, non-directed changes.
对37例临床怀疑有非特异性支气管高反应性的患者，在组胺支气管激发试验前后，采用以下参数进行了对比研究：流量-容积曲线、体描仪、单次呼吸肺量测定、毛细血管血气分析。可区分出四种反应类型：孤立性支气管反应、孤立性气体交换障碍、双重反应、无反应。仅在反映小气道功能障碍的流量数据（Vmax 25%）方面发现了诱发的气体交换障碍的相关性，而在基础肺功能参数方面未发现相关性。转移因子和转移系数不敏感，平均而言仅显示微小的、无方向性的变化。
