Schiff C, Milili M, Bossy D, Fougereau M
Centre d'immunologie INSERM-CNRS de Marseille-Luminy, Marseille, France.
Int Rev Immunol. 1992;8(2-3):135-45. doi: 10.3109/08830189209055569.
In pre-B cells, the mu chain is expressed at the cell surface in association with a "light chain surrogate" encoded by the V pre-B and the lambda-like genes. This mu-psi-L complex presumably triggers early steps of the B cell differentiation, possibly by controlling the Ig gene rearrangements. In the humans, the lambda-like complex contains 3 genes, located in the 22q11.2-q12.3 band, telomeric to the IGCL locus, with which they share a similar organization, pointing to a common genetic origin. Only one lambda-like gene, 14.1, is functional and specifically expressed with V pre-B in pre-B cells. This expression starts in cells which still have the IGH locus in germline configuration (pro-B stage) and ceases as soon as the IGL loci rearrange. These pre-B specific transcripts provide useful markers of cells of the B lineage in both physiological and pathological situations.
在前B细胞中，μ链与由V前B基因和类λ基因编码的“替代轻链”一起表达于细胞表面。这种μ-ψ-L复合物可能通过控制Ig基因重排来触发B细胞分化的早期步骤。在人类中，类λ复合物包含3个基因，位于22q11.2-q12.3带，在IGCL基因座的端粒位置，它们与IGCL基因座具有相似的组织结构，表明有共同的遗传起源。只有一个类λ基因，即14.1基因，具有功能并在前B细胞中与V前B基因特异性共表达。这种表达在仍具有种系构型的IGH基因座的细胞（前B细胞阶段）中开始，并在IGL基因座重排后立即停止。这些前B细胞特异性转录本在生理和病理情况下都是B系细胞的有用标志物。
