Rusthoven Esther, van der Vlugt Maartje E, van Lingen-van Bueren Lida J, van Schaijk Theodora C J G, Willems Hans L, Monnens Leo A H, Schröder Cornelis H
Department of Pediatric Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands.
Perit Dial Int. 2005 Jul-Aug;25(4):352-6.
To establish intraperitoneal pressure (IPP) in a relatively large pediatric study group and to study the effects of a 3.86% glucose solution and a 7.5% icodextrin solution on IPP during a 4-hour dwell.
IPP was measured with the patient in a supine position. The intraperitoneal volume (IPV) was 1200 mL/m2 with a 1.36% glucose solution. The influence of dialysis solutions was obtained by performing two 4-hour peritoneal equilibration tests (PETs) with 3.86% glucose and 7.5% icodextrin as test solution, using an IPV of 1200 mL/m2 and dextran 70 as volume marker. IPP was measured at two consecutive time points (t = 0 and t = 240 minutes). Transcapillary ultrafiltration, net ultrafiltration, and marker clearance were calculated.
IPP was established in 30 patients with median age of 4.5 years (range 1.0 - 14.9 years). Influence of dialysis solutions on IPP was studied in 9 children with median age of 4.2 years (range 1.7 - 10.9 years) and median treatment period of 12 months (range 5.6 - 122.3 months).
Mean IPP was 12.0 +/- 6.5 cm H2O. Significant relations were found between the change in IPP and transcapillary ultrafiltration and body surface area during the PET with 3.86% glucose. No relations were seen during the PET with icodextrin.
IPP was established in a large pediatric study group and was similar to previously published values of IPP in a small number of patients. Differences in fluid kinetics have different effects on the change in IPP during a 4-hour dwell period.
在一个相对较大的儿科研究组中建立腹腔内压力（IPP），并研究3.86%葡萄糖溶液和7.5%艾考糊精溶液在4小时驻留期间对IPP的影响。
患者仰卧位时测量IPP。使用1.36%葡萄糖溶液时腹腔容积（IPV）为1200 mL/m²。通过以3.86%葡萄糖和7.5%艾考糊精作为测试溶液进行两次4小时的腹膜平衡试验（PET）来获得透析液的影响，使用1200 mL/m²的IPV和右旋糖酐70作为容积标记物。在两个连续时间点（t = 0和t = 240分钟）测量IPP。计算跨毛细血管超滤、净超滤和标记物清除率。
在30名中位年龄为4.5岁（范围1.0 - 14.9岁）的患者中建立了IPP。在9名中位年龄为4.2岁（范围1.7 - 10.9岁）且中位治疗期为12个月（范围5.6 - 122.3个月）的儿童中研究了透析液对IPP的影响。
平均IPP为12.0 +/- 6.5 cm H₂O。在使用3.86%葡萄糖的PET期间，发现IPP变化与跨毛细血管超滤和体表面积之间存在显著关系。在使用艾考糊精的PET期间未发现相关性。
在一个大型儿科研究组中建立了IPP，其与先前在少数患者中发表的IPP值相似。在4小时驻留期内，液体动力学的差异对IPP变化有不同影响。
