Snyder Robert J
Wound Healing Center, University Hospital and Medical Center, Tamarac, FL 33321, USA.
Clin Dermatol. 2005 Jul-Aug;23(4):388-95. doi: 10.1016/j.clindermatol.2004.07.020.
Chronic wounds often represent a significant medical and economic challenge. Clinicians seek novel therapies poised to foster production of granulation tissue and subsequent healing. Cadaveric allograft remains the mainstay in burn therapy. Research, however, shows that this treatment functions adjunctively in complex nonhealing wounds by manipulating the microenvironment, preventing desiccation of underlying bone and tendon, augmenting wound-bed preparation, and producing rapid closure. The following review presents the rationale for incorporating skin allografts into the wound healing algorithm, including chronic wound biochemistry, wound-bed preparation, current applications, combination therapies, cost considerations, and case studies. Diagnosis and treatment of underlying etiologies remains essential. A multidisciplinary approach using accepted treatment protocols helps reduce morbidity and expense associated with these lesions.
慢性伤口往往构成重大的医学和经济挑战。临床医生寻求能够促进肉芽组织生成及后续愈合的新疗法。尸体同种异体移植物仍是烧伤治疗的主要手段。然而，研究表明，这种治疗方法通过操纵微环境、防止深层骨骼和肌腱干燥、加强创面准备以及实现快速闭合，在复杂的不愈合伤口中起到辅助作用。以下综述阐述了将皮肤同种异体移植物纳入伤口愈合方案的基本原理，包括慢性伤口生物化学、创面准备、当前应用、联合疗法、成本考量以及案例研究。潜在病因的诊断和治疗仍然至关重要。采用公认治疗方案的多学科方法有助于降低与这些损伤相关的发病率和费用。
