EDNAP小组关于Y染色体二元多态性分析的合作研究。
A collaborative study of the EDNAP group regarding Y-chromosome binary polymorphism analysis.
作者信息
Brion María, Dupuy Berit M, Heinrich Marielle, Hohoff Carsten, Hoste Bernardette, Ludes Bertrand, Mevag Bente, Morling Niels, Niederstätter Harald, Parson Walther, Sanchez Juan, Bender Klaus, Siebert Nathalie, Thacker Catherine, Vide Conceiçao, Carracedo Angel
机构信息
Institute of Legal Medicine, University of Santiago de Compostela, San Francisco s/n, 15782 Santiago de Compostela, Spain.
出版信息
Forensic Sci Int. 2005 Oct 29;153(2-3):103-8. doi: 10.1016/j.forsciint.2005.06.002.
A collaborative study was carried out by the European DNA Profiling Group (EDNAP) in order to evaluate the performance of Y-chromosome binary polymorphism analysis in different European laboratories. Four blood samples were sent to the laboratories, to be analysed for 11 Y-chromosome single nucleotide polymorphisms (SNPs): SRY-1532, M40, M35, M213, M9, 92R7, M17, P25, M18, M153 and M167. All the labs were also asked to submit a population study including these markers. All participating laboratories reported the same results, indicating the reproducibility and robustness of Y-chromosome SNP typing. A total of 535 samples from six different European populations were also analysed. In Galicia (NW Spain) and Belgium, the most frequent haplogroup was R1b*(xR1b1,R1b3df). Haplogroup F*(xK) is one of the most frequent in Austria and Denmark, while the lowest frequency appear in Belgium. Haplogroup frequencies found in this collaborative study were compared with previously published European Y-chromosome haplogroup data.
欧洲DNA分析小组（EDNAP）开展了一项合作研究，以评估不同欧洲实验室中Y染色体二元多态性分析的性能。四份血液样本被送往各实验室，用于分析11个Y染色体单核苷酸多态性（SNP）：SRY-1532、M40、M35、M213、M9、92R7、M17、P25、M18、M153和M167。所有实验室还被要求提交一项包含这些标记的群体研究。所有参与实验室报告的结果相同，表明Y染色体SNP分型具有可重复性和稳健性。还对来自六个不同欧洲人群的535个样本进行了分析。在加利西亚（西班牙西北部）和比利时，最常见的单倍群是R1b*（xR1b1，R1b3df）。单倍群F*（xK）在奥地利和丹麦最为常见，而在比利时出现的频率最低。将这项合作研究中发现的单倍群频率与先前发表的欧洲Y染色体单倍群数据进行了比较。
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