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对摩德纳男性(意大利北部)进行的慢进化和快进化标记分型

Slow and fast evolving markers typing in Modena males (North Italy).

作者信息

Ferri Gianmarco, Alù Milena, Corradini Beatrice, Radheshi Erjon, Beduschi Giovanni

机构信息

Department of Diagnostic and Laboratory Service and Legal Medicine, Section of Legal Medicine, University of Modena and Reggio Emilia, Italy.

出版信息

Forensic Sci Int Genet. 2009 Mar;3(2):e31-3. doi: 10.1016/j.fsigen.2008.05.004. Epub 2008 Jun 20.

Abstract

One hundred thirty male individuals, strictly selected for their geographical origin and for typical regional surnames were submitted to the analysis. 17 STRs (short tandem repeats) loci and 19 SNPs binary markers (single nucleotide polymorphisms) of male-specific region of the Y chromosome (MSY) were typed to well characterize the selected population of Modena province. The availability of joint distribution of MSY haplotypes and haplogroup frequencies is becoming an important tool for both human evolutionary studies and forensic investigation, but large databases of complete Y-lineages are needed for a better understanding of the power of the combined use of Y-specific polymorphisms. A total of 129 haplotypes and 9 haplogroups were found and R1b haplogroup with a frequency of 67.7% was the most frequent, as expected because of the geographical location of the sample (Northwestern Italy). The Modena Y-lineages (STRs and SNPs independently) were also compared with published data of other neighbouring populations' samples.

摘要

130名男性个体,因其地理来源和典型的地区姓氏而被严格挑选出来接受分析。对Y染色体男性特异区(MSY)的17个短串联重复序列(STR)位点和19个单核苷酸多态性(SNP)二元标记进行分型,以充分表征摩德纳省选定的人群。MSY单倍型和单倍群频率的联合分布对于人类进化研究和法医调查而言正成为一种重要工具,但需要大量完整Y系谱数据库,以便更好地理解Y特异性多态性联合使用的效能。共发现129种单倍型和9个单倍群,频率为67.7%的R1b单倍群最为常见,鉴于样本的地理位置(意大利西北部),这在意料之中。还将摩德纳Y系谱(分别为STR和SNP)与其他邻近人群样本的已发表数据进行了比较。

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