Tarin David, Thompson Erik W, Newgreen Donald F
Rebecca and John Moores Cancer Center and Department of Pathology, University of California, San Diego, San Diego, California, USA.
Cancer Res. 2005 Jul 15;65(14):5996-6000; discussion 6000-1. doi: 10.1158/0008-5472.CAN-05-0699.
Epithelial mesenchymal transition has been postulated as a versatile mechanism which facilitates cellular repositioning and redeployment during embryonic development, tissue reconstruction after injury, carcinogenesis, and tumor metastasis. The hypothesis originates from parallels drawn between the morphology and behavior of locomotory and sedentary cells in vitro and in various normal and pathologic processes in vivo. This review analyzes data from several studies on embryonic development, wound healing, and the pathology of human tumors, including work from our own laboratory, to assess the validity of the proposal. It is concluded that there is no convincing evidence for conversion of epithelial cells into mesenchymal cell lineages in vivo and that the biological repertoire of normal and malignant cells is sufficient to account for the events and processes observed, without needing to invoke radical changes in cell identity.
上皮-间质转化被认为是一种多功能机制，它在胚胎发育、损伤后的组织重建、癌症发生和肿瘤转移过程中促进细胞重新定位和重新部署。该假说源于体外运动细胞和静止细胞的形态与行为，以及体内各种正常和病理过程之间的相似性。这篇综述分析了多项关于胚胎发育、伤口愈合和人类肿瘤病理学研究的数据，包括我们自己实验室的研究成果，以评估该提议的有效性。结论是，没有令人信服的证据表明体内上皮细胞会转化为间充质细胞谱系，而且正常细胞和恶性细胞的生物学特性足以解释所观察到的事件和过程，无需假定细胞身份发生根本性变化。
