聚焦上皮-间质转化的转录因子生物标志物与靶向治疗的最新进展
Recent Advances in Transcription Factors Biomarkers and Targeted Therapies Focusing on Epithelial-Mesenchymal Transition.
作者信息
Chuang Kai-Ting, Chiou Shyh-Shin, Hsu Shih-Hsien
机构信息
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
出版信息
Cancers (Basel). 2023 Jun 25;15(13):3338. doi: 10.3390/cancers15133338.
Abstract
Transcription factors involve many proteins in the process of transactivating or transcribing (none-) encoded DNA to initiate and regulate downstream signals, such as RNA polymerase. Their unique characteristic is that they possess specific domains that bind to specific DNA element sequences called enhancer or promoter sequences. Epithelial-mesenchymal transition (EMT) is involved in cancer progression. Many dysregulated transcription factors-such as Myc, SNAIs, Twists, and ZEBs-are key drivers of tumor metastasis through EMT regulation. This review summarizes currently available evidence related to the oncogenic role of classified transcription factors in EMT editing and epigenetic regulation, clarifying the roles of the classified conserved transcription factor family involved in the EMT and how these factors could be used as therapeutic targets in future investigations.
摘要
转录因子在将（非）编码DNA反式激活或转录以启动和调节下游信号（如RNA聚合酶）的过程中涉及多种蛋白质。它们的独特特征是拥有与称为增强子或启动子序列的特定DNA元件序列结合的特定结构域。上皮-间质转化（EMT）与癌症进展有关。许多失调的转录因子，如Myc、SNAI、Twist和ZEB，是通过EMT调节促进肿瘤转移的关键驱动因素。本综述总结了目前与分类转录因子在EMT编辑和表观遗传调控中的致癌作用相关的证据，阐明了参与EMT的分类保守转录因子家族的作用，以及这些因子在未来研究中如何用作治疗靶点。
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