氨甲环酸对玻璃体切除术后早期糖尿病性出血的影响；一项随机临床试验。
Effect of tranexamic acid on early postvitrectomy diabetic haemorrhage; a randomised clinical trial.
作者信息
Ramezani A R, Ahmadieh H, Ghaseminejad A K, Yazdani S, Golestan B
机构信息
Ophthalmic Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Br J Ophthalmol. 2005 Aug;89(8):1041-4. doi: 10.1136/bjo.2004.062638.
AIMS
To evaluate the effect of tranexamic acid on early postvitrectomy haemorrhage in diabetic patients.
METHODS
In a clinical trial, 62 diabetic patients scheduled for vitrectomy were randomly assigned to two groups. The treatment group (32 eyes) received two doses of tranexamic acid (10 mg/kg) shortly before and after the operation intravenously, continued orally for 4 days (20 mg/kg/8 hours). The control group (30 eyes) received no medication. Both media clarity and visual acuity were compared during 4 weeks.
RESULTS
Four weeks after surgery visual acuity was low (< or =1 metre counting fingers) in 21.4%, moderate (>1 metre counting fingers but<20/200) in 14.3%, and good (> or =20/200) in 64.3% of the treated group. Corresponding figures in the control group were 26.1%, 26.1%, and 47.8%, respectively. These differences were of no statistical significance. The ratio of mild to severe vitreous haemorrhage during the first 4 days and after 4 weeks was 79% to 21% and 82% to 18% in the treatment group and 76.7% to 23.3% and 78.3% to 21.7% in the control group respectively, which showed no statistically significant difference.
CONCLUSION
Tranexamic acid, with the method of administration in this study, had no effect on reducing early postvitrectomy haemorrhage in diabetic patients.
目的
评估氨甲环酸对糖尿病患者玻璃体切除术后早期出血的影响。
方法
在一项临床试验中，将62例计划接受玻璃体切除术的糖尿病患者随机分为两组。治疗组（32只眼）在手术前后不久静脉注射两剂氨甲环酸（10mg/kg），并持续口服4天（20mg/kg/8小时）。对照组（30只眼）不接受任何药物治疗。在4周内比较两组的介质清晰度和视力。
结果
治疗组术后4周时，视力低（≤1米指数）的患者占21.4%，视力中等（>1米指数但<20/200）的患者占14.3%，视力良好（≥20/200）的患者占64.3%。对照组相应的数据分别为26.1%、26.1%和47.8%。这些差异无统计学意义。治疗组前4天和4周后轻度至重度玻璃体出血的比例分别为79%至21%和82%至18%，对照组分别为76.7%至23.3%和78.3%至21.7%，差异无统计学意义。
结论
本研究采用的氨甲环酸给药方法对减少糖尿病患者玻璃体切除术后早期出血无效。
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