Verdoorn C, Hendrikse F
Institute of Ophthalmology, University of Nijmegen, The Netherlands.
Ophthalmic Surg. 1989 Apr;20(4):278-9.
The effectiveness of intravitreal thrombin infusion during vitrectomy was prospectively evaluated in eight diabetic patients with persistent vitreous hemorrhages and severe proliferative vitreoretinopathy. A concentration of 80 units/ml of human thrombin diluted in BSS-plus infusion fluid was used. Bleeding time ranged between 2 and 15 seconds (mean, 5 seconds). The reduction of bleeding facilitated surgery. In five of the eight cases the vitreous was clear one day postoperatively. One month postoperatively six eyes had clear media. No additional postoperative intraocular inflammation developed. These results suggest that human thrombin causes less inflammation than bovine thrombin.
对8例患有持续性玻璃体积血和严重增殖性玻璃体视网膜病变的糖尿病患者，前瞻性评估了玻璃体切割术中玻璃体内注入凝血酶的有效性。使用在平衡盐溶液（BSS）+输液中稀释至80单位/毫升浓度的人凝血酶。出血时间在2至15秒之间（平均5秒）。出血减少有利于手术操作。8例中有5例在术后一天玻璃体腔变清晰。术后一个月，6只眼的屈光间质清晰。未出现额外的术后眼内炎症。这些结果表明，人凝血酶比牛凝血酶引起的炎症更少。
