Kaikkonen K S, Kakko S, Kortelainen M L, Tapanainen J M, Savolainen M J, Antero Kesäniemi Y, Huikuri H V, Savolainen E R
Division of Cardiology, Department of Internal Medicine, University of Oulu, Finland.
Scand J Clin Lab Invest. 2005;65(2):133-40. doi: 10.1080/00365510510013550.
A common polymorphism (-1C to T) in the translation initiation sequence of annexin A5 (ANV) gene has recently been associated with a decreased risk of acute myocardial infarction (AMI). The aim of the present study was to analyze the association between the ANV genepolymorphism and the risk of AMI and ischemic sudden cardiac death (SCD) in middle-aged Finnish males.
A case-control study involving three distinct groups of subjects was carried out: (1) victims of SCD (n=98), (2) survivors of AMI (n=212), and (3) randomly selected control subjects without any history of coronary heart disease (n=243). The ANV polymorphism was genotyped in each study group.
Among the control group of healthy Finnish males the prevalence rates of the CC, CT, and TT genotypes were 83.1%, 15.2%, and 1.6%, respectively. Among the survivors of AMI, the prevalence rates of CC, CT, and TT were 79.7%, 20.3%, and 0%, respectively, and among the victims of SCD 83.7%, 16.3%, and 0%, respectively. No significant differences in the genotype or allele distributions were observed between the study groups.
The -1C to T polymorphism in the ANV gene is not associated with the risk of AMI or SCD in middle-aged Finnish males.
膜联蛋白A5（ANV）基因翻译起始序列中一种常见的多态性（-1C至T）最近被发现与急性心肌梗死（AMI）风险降低有关。本研究的目的是分析芬兰中年男性中ANV基因多态性与AMI风险及缺血性心源性猝死（SCD）之间的关联。
进行了一项病例对照研究，涉及三组不同的受试者：（1）SCD受害者（n = 98），（2）AMI幸存者（n = 212），以及（3）随机选择的无冠心病病史的对照受试者（n = 243）。对每个研究组的ANV多态性进行基因分型。
在健康芬兰男性对照组中，CC、CT和TT基因型的患病率分别为83.1%、15.2%和1.6%。在AMI幸存者中，CC、CT和TT的患病率分别为79.7%、20.3%和0%，在SCD受害者中分别为83.7%、16.3%和0%。各研究组之间在基因型或等位基因分布上未观察到显著差异。
ANV基因中-1C至T多态性与芬兰中年男性的AMI或SCD风险无关。
