Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Forensic Medicine Unit, Finnish Institute for Health and Welfare, Oulu, Finland.
Ann Med. 2021 Dec;53(1):413-419. doi: 10.1080/07853890.2021.1890204.
Non-ischaemic heart disease (NIHD) is the underlying pathology in∼20% of all sudden cardiac deaths (SCDs). Heavy drinking is known to be associated with SCD due to ischaemic heart disease, but studies on association of recent alcohol consumption and SCD in patients with NIHD are scarce. We evaluated the blood alcohol levels of autopsy verified non-ischaemic SCD victims.
Study population was derived from the Finnish Genetic Study of Arrhythmic Events (Fingesture) ( = 5869, mean age 65 ± 12, 79% males). All deaths occurred in Northern Finland during 1998-2017. All victims underwent a medico-legal autopsy. Subjects of SCD due to ischaemic heart disease were excluded.
A total of 1301 (mean age 57 ± 12, 78% males) victims of SCD due to NIHD were included in the study. The blood ethanol level was elevated in 543 (42%) subjects, out of which the blood alcohol level was ≥0.10%in 339 (62%) subjects and ≥0.15%in 252 (46%) subjects. Male SCD victims had alcohol in blood more frequently compared to females (45% versus 31%, < .001).
Elevated blood alcohol level is common in SCD victims due to NIHD, especially in males. Recent alcohol consumption might contribute to the subsequent SCD in many non-ischaemic SCD victims.KEY MESSAGESElevated blood alcohol level is common in victims of sudden cardiac death due to non-ischaemic heart disease, especially in males.Recent alcohol consumption may contribute to the subsequent death in many nonischemic sudden cardiac death victims.
非缺血性心脏病（NIHD）是所有心源性猝死（SCD）的潜在病理基础。已知大量饮酒会导致缺血性心脏病相关的 SCD，但关于近期饮酒与 NIHD 患者 SCD 之间关联的研究却很少。我们评估了经尸检证实的非缺血性 SCD 患者的血液酒精水平。
研究人群来自芬兰心律失常事件遗传研究（Fingesture）（ = 5869，平均年龄 65±12 岁，79%为男性）。所有死亡均发生在 1998 年至 2017 年期间的芬兰北部。所有受害者均接受了医学法律尸检。排除因缺血性心脏病导致 SCD 的患者。
本研究共纳入 1301 例（平均年龄 57±12 岁，78%为男性）因 NIHD 导致的 SCD 患者。543 例（42%）患者血液乙醇水平升高，其中 339 例（62%）患者血液酒精水平≥0.10%，252 例（46%）患者血液酒精水平≥0.15%。与女性相比，男性 SCD 患者血液中酒精更为常见（45%比 31%， < .001）。
NIHD 导致的 SCD 患者血液中酒精水平升高很常见，尤其是男性。近期饮酒可能导致许多非缺血性 SCD 患者随后发生 SCD。
非缺血性心脏病导致的心源性猝死患者血液中酒精水平升高很常见，尤其是男性。近期饮酒可能导致许多非缺血性心源性猝死患者随后死亡。
