H2 受体参与酪氨酰-促黑素细胞激素释放抑制因子-1 的镇痛作用机制。
Involvement of H2-receptors in the mechanism of analgesic action of Tyr-MIF-1.
作者信息
Zamfirova R, Bocheva A, Todorov S
机构信息
Institute of Physiology, Bulgarian Academy of Sciences, Bulgaria.
出版信息
Arch Physiol Biochem. 2003 Dec;111(5):443-7. doi: 10.3109/13813450312331342300.
The antinociceptive effects of H2-agents cimetidine (CIM) and dimaprit (DMP) as well as their effects on the Tyr-MIF-1-evoked analgesia have been studied after intraperitoneal (i.p.) administration in rats. In the paw-pressure (PP) test Tyr-MIF-1 (1 mg/kg), CIM (50 and 100mg/kg) and DMP (5 and 10mg/kg) induced analgesia. Injected before DMP, naloxone (NAL) and CIM diminished or completely prevented the pain-relieving effect of H2-agonist DMP. The antinociceptive effect of Tyr-MIF-1 has been potentiated by DMP dose-dependently. CIM (50mg/kg) decreased the antinociceptive action of the combination Tyr-MIF-1 + DMP, while CIM (100mg/kg) expressed a weaker inhibitory effect on it. The data obtained clearly show that H2-receptor activation is involved in the mechanism of the Tyr-MIF-1 antinociceptive action.
在大鼠腹腔注射后，研究了H2受体拮抗剂西咪替丁（CIM）和二甲双胍（DMP）的抗伤害感受作用及其对酪氨酰-促黑素细胞激素-1（Tyr-MIF-1）诱发镇痛的影响。在 paw-pressure（PP）试验中，Tyr-MIF-1（1mg/kg）、CIM（50和100mg/kg）和DMP（5和10mg/kg）均诱导产生镇痛作用。在注射DMP之前注射纳洛酮（NAL）和CIM可减弱或完全阻止H2激动剂DMP的止痛效果。DMP剂量依赖性地增强了Tyr-MIF-1的抗伤害感受作用。CIM（50mg/kg）降低了Tyr-MIF-1 + DMP组合的抗伤害感受作用，而CIM（100mg/kg）对其表现出较弱的抑制作用。获得的数据清楚地表明，H2受体激活参与了Tyr-MIF-1抗伤害感受作用的机制。
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