酪氨酰-促黑素细胞激素释放抑制因子-1减弱由三种应激镇痛模型诱导的抗伤害感受反应。
Tyr-MIF-1 attenuates antinociceptive responses induced by three models of stress-analgesia.
作者信息
Galina Z H, Kastin A J
出版信息
Br J Pharmacol. 1987 Apr;90(4):669-74. doi: 10.1111/j.1476-5381.1987.tb11219.x.
Abstract
Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), a biologically active brain peptide, has previously been shown to antagonize the analgesia induced by morphine. In this report experiments are described in which mice were tested on the hot-plate in three models of antinociception - shock, novel environment, and warm-water swim - after the administration of various doses of Tyr-MIF-1 without any exogenous opiates. The peptide reduced the antinociception produced by all three methods of inducing endogenous antinociception. These results add further support for the existence of peptides like Tyr-MIF-1 that act as opiate antagonists.
摘要
酪氨酰-促黑素细胞激素释放抑制因子-1（Tyr-Pro-Leu-Gly-NH2）是一种具有生物活性的脑肽，此前已被证明可拮抗吗啡诱导的镇痛作用。在本报告中，描述了这样的实验：给小鼠注射不同剂量的酪氨酰-促黑素细胞激素释放抑制因子-1且不使用任何外源性阿片类药物后，在三种抗伤害感受模型——电击、新环境和温水游泳模型中，利用热板对小鼠进行测试。该肽降低了通过三种诱导内源性抗伤害感受方法所产生的抗伤害感受作用。这些结果进一步支持了像酪氨酰-促黑素细胞激素释放抑制因子-1这样作为阿片拮抗剂发挥作用的肽的存在。
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