西咪替丁不会改变酪氨酰-促黑素细胞激素-1（酪氨酰-脯氨酰-亮氨酰-甘氨酰胺）对足部电击所致阿片类镇痛形式的作用。

Cimetidine does not change the effect of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on the opiate form of footshock-induced analgesia.

作者信息

Krowicki Z K

机构信息

Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70146.

出版信息

Life Sci. 1991;49(16):1163-8. doi: 10.1016/0024-3205(91)90563-q.

DOI:10.1016/0024-3205(91)90563-q

PMID:1680211

Abstract

It has been demonstrated that cimetidine blocks the effect of naloxone on footshock-induced analgesia. To study the effect of cimetidine on the antiopiate properties of an endogenous peptide Tyr-MIF-1, the opiate form of intermittent footshock-induced analgesia was elicited in the rat. The nociceptive responses were determined using the hot-plate test (52.5 degrees C). Intraperitoneal pretreatment with cimetidine (100 mg/kg) or chlorpheniramine maleate (20 mg/kg) did not affect the footshock-induced analgesia, and did not change the antagonizing effect of Tyr-MIF-1 (0.2 mg/kg) on this model of antinociception. It is concluded that cimetidine and chlorpheniramine maleate do not change the antagonizing effect of Tyr-MIF-1 on the opiate form of intermittent footshock-induced analgesia.

摘要

已证实西咪替丁可阻断纳洛酮对足部电击诱导镇痛的作用。为研究西咪替丁对内源性肽Tyr-MIF-1抗阿片特性的影响，在大鼠中引发了间歇性足部电击诱导镇痛的阿片形式。使用热板试验（52.5摄氏度）测定伤害性反应。腹腔内预先给予西咪替丁（100毫克/千克）或马来酸氯苯那敏（20毫克/千克）不影响足部电击诱导的镇痛，且不改变Tyr-MIF-1（0.2毫克/千克）对该镇痛模型的拮抗作用。结论是西咪替丁和马来酸氯苯那敏不改变Tyr-MIF-1对间歇性足部电击诱导镇痛的阿片形式的拮抗作用。