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细胞黄素在脊髓压迫性损伤中的神经保护作用。

Neuroprotective effect of cytoflavin during compression injury of the spinal cord.

作者信息

Bul'on V V, Kuznetsova N N, Selina E N, Kovalenko A L, Alekseeva L E, Sapronov N S

机构信息

Department of Neuropharmacology, Institute of Experimental Medicine, Russia.

出版信息

Bull Exp Biol Med. 2005 Apr;139(4):394-6. doi: 10.1007/s10517-005-0303-5.

DOI:10.1007/s10517-005-0303-5
PMID:16027862
Abstract

Cytoflavin normalized energy metabolism, decreased the intensity of lipid peroxidation, and reactivated the antioxidant system in the spinal cord of rats with compression injury at the level of Th10-Th11. The neuroprotective effect of the test preparation manifested in normalization of hindlimb motor function and decrease in mortality rate of animals with spinal cord injury. Neuroprotective activity of cytoflavin was higher than that of Cerebrolysin.

摘要

细胞黄素使能量代谢正常化,降低脂质过氧化强度,并使胸10 - 胸11水平压缩性损伤大鼠脊髓中的抗氧化系统重新激活。受试制剂的神经保护作用表现为后肢运动功能正常化以及脊髓损伤动物死亡率降低。细胞黄素的神经保护活性高于脑蛋白水解物。

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