Straub Rainer H, Pongratz Georg, Weidler Claudia, Linde Hans-Jörg, Kirschning Carsten J, Glück Thomas, Schölmerich Jürgen, Falk Werner
Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.
J Infect Dis. 2005 Aug 15;192(4):560-72. doi: 10.1086/432134. Epub 2005 Jul 15.
The sympathetic nervous system is intensely activated during bacteremia, but its immediate influence on the bacterial tissue burden remains unclear. We demonstrate that prior ablation of the sympathetic nervous system decreases this dissemination of Pseudomonas aeruginosa or Escherichia coli through a mechanism of increased secretion of peritoneal tumor necrosis factor, improved phagocytic response of peritoneal cells, and increased influx of monocytes into the peritoneal cavity. When gram-positive Staphylococcus aureus strains were used, sympathectomy increased the bacterial tissue burden, which was caused by a reduction in corticosterone tonus, and decreased both interleukin-4 secretion from peritoneal cells and the influx of lymphocytes into the peritoneal cavity. In both models, the peritoneal wall was the critical border for systemic infection. These results show the dual role of the sympathetic nervous system in sepsis. It can be favorable or unfavorable, depending on the innate immune effector mechanisms necessary to overcome infection.
在菌血症期间，交感神经系统会被强烈激活，但其对细菌组织负荷的直接影响仍不清楚。我们证明，预先切除交感神经系统可通过增加腹膜肿瘤坏死因子的分泌、改善腹膜细胞的吞噬反应以及增加单核细胞流入腹膜腔的机制，减少铜绿假单胞菌或大肠杆菌的这种播散。当使用革兰氏阳性金黄色葡萄球菌菌株时，交感神经切除术会增加细菌组织负荷，这是由皮质酮张力降低引起的，同时会减少腹膜细胞白细胞介素-4的分泌以及淋巴细胞流入腹膜腔的数量。在这两种模型中，腹膜壁都是全身感染的关键边界。这些结果表明交感神经系统在脓毒症中具有双重作用。根据克服感染所需的固有免疫效应机制，它可能是有利的，也可能是不利的。
