Raspollini Maria Rosaria, Taddei Gian Luigi, Marchionni Mauro, Bacci Stefano, Romagnoli Paolo
Department of Human Pathology and Oncology, University of Florence, School of Medicine, Florence, Italy.
Ultrastruct Pathol. 2005 Mar-Apr;29(2):149-55. doi: 10.1080/019131290924072.
Uterine carcinosarcomas are biphasic neoplasms with carcinomatous and sarcomatous elements. However, several elements suggest that carcinosarcomas may be more closely related to carcinoma of the endometrium and that they arise from an unique stem cell. Recently, the authors observed an uterine tumor that at histologic examination showed an apparently double population of cells: malignant epithelial element admixed with mesenchymal spindle-shaped cells. The immunohistochemical stainings instead showed cytokeratin positivity and negativity for stromal markers. Electron microscopy showed the neoplastic tissue to be made of a single population of poorly differentiated epithelial cells, thus confirming the immunohistochemical findings and leading to the diagnosis of uterine metaplastic carcinoma.
子宫癌肉瘤是具有癌性和肉瘤性成分的双相肿瘤。然而，有几个因素表明癌肉瘤可能与子宫内膜癌关系更为密切，且它们起源于一种独特的干细胞。最近，作者观察到一例子宫肿瘤，组织学检查显示明显有两种细胞群：恶性上皮成分与间充质梭形细胞混合存在。相反，免疫组化染色显示细胞角蛋白呈阳性，而间质标志物呈阴性。电子显微镜检查显示肿瘤组织由单一的低分化上皮细胞群构成，从而证实了免疫组化结果，并得出子宫化生性癌的诊断。
