Grindstaff Samuel, Hanley Linda C, Banet Natalie
Int J Gynecol Pathol. 2022 Jan 1;41(1):40-44. doi: 10.1097/PGP.0000000000000774.
Yolk sac tumor of the endometrium is an uncommon neoplasm. Here we report a case of yolk sac tumor arising in a uterine carcinosarcoma, with the carcinomatous component showing both endometrioid and serous components, and the sarcomatous component showing homologous (spindled) differentiation. The yolk sac tumor showed predominant glandular configuration and was present admixed with the epithelial components. Extensive immunostaining was performed to narrow the differential diagnosis, including potentially therapeutic testing for HER-2. To our knowledge, this is the first case of carcinosarcoma with this mix of epithelial components and corresponding reporting of these immune and therapeutic markers.
子宫内膜卵黄囊瘤是一种罕见的肿瘤。在此我们报告一例发生于子宫癌肉瘤的卵黄囊瘤病例，其中癌性成分表现为子宫内膜样和浆液性成分，肉瘤性成分表现为同源性（梭形）分化。卵黄囊瘤以腺管状结构为主，与上皮成分混合存在。进行了广泛的免疫染色以缩小鉴别诊断范围，包括对HER-2进行潜在的治疗性检测。据我们所知，这是首例具有这种上皮成分组合且报告了这些免疫和治疗标志物的癌肉瘤病例。
