罗利那他汀1、罗利膜菌素和膜那辛的立体选择性合成。

Stereoselective syntheses of rolliniastatin 1, rollimembrin, and membranacin.

作者信息

Keum Gyochang, Hwang Cheol Hee, Kang Soon Bang, Kim Youseung, Lee Eun

机构信息

Department of Chemistry, College of Natural Sciences, Seoul National University NS60, Seoul 151-747, Korea.

出版信息

J Am Chem Soc. 2005 Jul 27;127(29):10396-9. doi: 10.1021/ja0526867.

DOI:10.1021/ja0526867

PMID:16028952

Abstract

A radical cyclization of beta-alkoxyvinyl sulfoxides-Pummerer rearrangement-allylation protocol was successfully applied to the synthesis of the threo/cis/threo/cis/erythro bis-oxolane moiety in rolliniastatin 1 (1), rollimembrin (2), and membranacin (3).

摘要

一种β-烷氧基乙烯基亚砜的自由基环化-Pummerer重排-烯丙基化反应方案成功应用于罗利他汀1（1）、罗利膜蛋白（2）和膜脂酸（3）中苏式/顺式/苏式/顺式/赤藓糖型双氧杂环戊烷部分的合成。