使用近红外受体靶向造影剂对人前列腺癌组织进行光谱偏振成像。

Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent.

作者信息

Pu Y, Wang W B, Tang G C, Zeng F, Achilefu S, Vitenson J H, Sawczuk I, Peters S, Lombardo J M, Alfano R R

机构信息

Department of Electrical Engineering, The City College of the City Univ. of NY, Convent Avenue at 138th Street, New York, NY 10031, USA.

出版信息

Technol Cancer Res Treat. 2005 Aug;4(4):429-36. doi: 10.1177/153303460500400410.

DOI:10.1177/153303460500400410

PMID:16029061

Abstract

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

摘要

西派特-蛙皮素肽类似物缀合物（Cybesin）被用作前列腺肿瘤受体靶向造影剂。对Cybesin的吸收光谱和荧光光谱进行了测量，结果表明其存在于近红外组织“光学窗口”中。对经Cybesin染色的前列腺癌组织和正常组织进行光谱偏振成像显示，前列腺癌组织比前列腺正常组织摄取更多的Cybesin，这使得Cybesin成为前列腺癌的一个潜在标志物。