Komiyama Tomoko
University of Michigan Medical School, Department of Biological Chemistry, Ann Arbor, MI 48109, USA.
Protein Pept Lett. 2005 Jul;12(5):415-20. doi: 10.2174/0929866054395220.
Potent inhibitors of the Kex2/furin family precursor processing proteases were developed by randomizing adventitious contact sites and screening for optimized affinity using inhibition assays in 96-well format [1]. In this review, the binding interactions of the developed inhibitors will be examined in light of the three dimensional structures of Kex2 and furin [2-4].
通过随机化偶然接触位点并使用96孔板抑制试验筛选优化亲和力，开发出了Kex2/弗林蛋白酶家族前体加工蛋白酶的强效抑制剂[1]。在这篇综述中，将根据Kex2和弗林蛋白酶的三维结构[2-4]来研究已开发抑制剂的结合相互作用。
