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1
Subtleties among subtilases. The structural biology of Kex2 and furin-related prohormone convertases.枯草杆菌蛋白酶之间的细微差别。Kex2和弗林蛋白酶相关激素原转化酶的结构生物学。
EMBO Rep. 2003 Oct;4(10):937-8. doi: 10.1038/sj.embor.embor946.
2
The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing.最温和的切割：Kex2和弗林蛋白酶的晶体结构揭示前体加工的秘密。
Trends Biochem Sci. 2004 Feb;29(2):80-7. doi: 10.1016/j.tibs.2003.12.006.
3
Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases.Kex2和弗林蛋白酶中底物选择性差异的结构基础。
Biochemistry. 2004 Mar 9;43(9):2412-21. doi: 10.1021/bi035849h.
4
Interaction of EGLIN C variants with the extended subsites of the precursor processing proteases.埃格林C变体与前体加工蛋白酶扩展亚位点的相互作用。
Protein Pept Lett. 2005 Jul;12(5):415-20. doi: 10.2174/0929866054395220.
5
Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin.扩展亚位点的可塑性促进了Kex2和弗林蛋白酶对不同底物的识别。
J Biol Chem. 2004 Aug 20;279(34):35656-63. doi: 10.1074/jbc.M405362200. Epub 2004 May 24.
6
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity.基于弗林蛋白酶和凯新蛋白酶晶体结构的前体蛋白转化酶模型：对其特异性的解释。
J Mol Biol. 2005 Jan 14;345(2):211-27. doi: 10.1016/j.jmb.2004.10.050.
7
Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2.典型前体蛋白转化酶Kex2中对精氨酸和赖氨酸的差异性识别
Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6626-31. doi: 10.1073/pnas.0701983104. Epub 2007 Apr 10.
8
Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors.哺乳动物蛋白原转化酶结合口袋的比较研究及其对特异性小分子抑制剂设计的意义。
Int J Biol Sci. 2010 Feb 3;6(1):89-95. doi: 10.7150/ijbs.6.89.
9
Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin.工程化的依吉林c变体可抑制酵母和人类前蛋白加工蛋白酶Kex2和弗林蛋白酶。
Biochemistry. 2000 Dec 12;39(49):15156-65. doi: 10.1021/bi001907c.
10
Specificity characterization of the α-mating factor hormone by Kex2 protease.Kex2蛋白酶对α-交配因子激素的特异性表征
Biochimie. 2016 Dec;131:149-158. doi: 10.1016/j.biochi.2016.10.003. Epub 2016 Oct 5.

引用本文的文献

1
Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris.白色念珠菌、光滑念珠菌、酿酒酵母和巴斯德毕赤酵母中真菌Kex2蛋白酶预测底物的加工过程。
BMC Microbiol. 2008 Jul 14;8:116. doi: 10.1186/1471-2180-8-116.
2
Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2.典型前体蛋白转化酶Kex2中对精氨酸和赖氨酸的差异性识别
Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6626-31. doi: 10.1073/pnas.0701983104. Epub 2007 Apr 10.

本文引用的文献

1
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.前蛋白加工蛋白酶弗林蛋白酶的晶体结构解释了其严格的特异性。
Nat Struct Biol. 2003 Jul;10(7):520-6. doi: 10.1038/nsb941.
2
2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor.2.4 典型的激素加工蛋白酶Kex2与丙氨酸-赖氨酸-精氨酸硼酸抑制剂复合物的解析晶体结构。
Biochemistry. 2003 Jun 10;42(22):6709-18. doi: 10.1021/bi034434t.
3
Furin at the cutting edge: from protein traffic to embryogenesis and disease.弗林蛋白酶处于前沿：从蛋白质运输到胚胎发育及疾病
Nat Rev Mol Cell Biol. 2002 Oct;3(10):753-66. doi: 10.1038/nrm934.
4
Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus.小家鼠激素原转化酶1前结构域的溶液结构
J Mol Biol. 2002 Jul 19;320(4):801-12. doi: 10.1016/s0022-2836(02)00543-0.
5
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.弗林蛋白酶分子内伴侣的有序且特定区域的自蛋白水解去除是酶激活所必需的。
J Biol Chem. 2002 Apr 12;277(15):12879-90. doi: 10.1074/jbc.M108740200. Epub 2002 Jan 17.
6
Differential utilization of enzyme-substrate interactions for acylation but not deacylation during the catalytic cycle of Kex2 protease.在Kex2蛋白酶催化循环中，酶 - 底物相互作用在酰化而非去酰化过程中的差异利用。
J Biol Chem. 2001 Oct 19;276(42):38394-9. doi: 10.1074/jbc.M105782200. Epub 2001 Aug 20.
7
Direct measurement of acylenzyme hydrolysis demonstrates rate-limiting deacylation in cleavage of physiological sequences by the processing protease Kex2.对酰基酶水解的直接测量表明，在加工蛋白酶Kex2切割生理序列的过程中，脱酰基是限速步骤。
Biochemistry. 2001 Mar 27;40(12):3657-65. doi: 10.1021/bi0020877.
8
Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides.弗林蛋白酶特异性的定量表征。使用一组内部一致的六肽基甲基香豆素酰胺进行底物识别的能量学研究。
J Biol Chem. 1999 Aug 13;274(33):23229-34. doi: 10.1074/jbc.274.33.23229.
9
Proteolytic processing in the secretory pathway.分泌途径中的蛋白水解加工。
J Biol Chem. 1999 Jul 23;274(30):20745-8. doi: 10.1074/jbc.274.30.20745.
10
Quantitative assessment of enzyme specificity in vivo: P2 recognition by Kex2 protease defined in a genetic system.体内酶特异性的定量评估：在遗传系统中定义的Kex2蛋白酶对P2的识别。
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10384-9. doi: 10.1073/pnas.95.18.10384.

枯草杆菌蛋白酶之间的细微差别。Kex2和弗林蛋白酶相关激素原转化酶的结构生物学。

Subtleties among subtilases. The structural biology of Kex2 and furin-related prohormone convertases.

作者信息

Brenner Charles

机构信息

Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, 1 Medical Center Drive HB7937, Lebanon, New Hampshire 03756, USA.

出版信息

EMBO Rep. 2003 Oct;4(10):937-8. doi: 10.1038/sj.embor.embor946.

DOI:10.1038/sj.embor.embor946
PMID:14528262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1326404/
Abstract

The structural biology of Kex2 and furin-related prohormone convertases

摘要

Kex2及弗林蛋白酶相关激素原转化酶的结构生物学