Adesiyun A A, Lenz W, Schaal K P
School of Veterinary Medicine, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad.
Microbiologica. 1992 Apr;15(2):125-33.
The production frequency of toxic shock syndrome toxin-1 (TSST-1) amongst Staphylococcus aureus strains isolated from humans, animals and foods in Nigeria was investigated. Of 1015 strains tested, 120 (11.8%) were positive for TSST-1. Thirty one (16.0%) of 194 strains from human diarrhoea and wounds were positive compared to 47 (7.1%) of 666 isolates from eight animal species. Goat strains were most often positive for this toxin (17.0%). A total of 42 (27.1%) of 155 strains from foods were positive for TSST-1. Regardless of source, phage non-typable strains (48.3%) were most common amongst TSST-1 producers followed by strains sensitive to phages in several groups (mixed), 18.3%, and phage group III strains (17.5%). Only 6 were phage group I strains (5.0%). TSST-1 producing strains were mostly resistant to penicillin. Eighty-four (70.0%) TSST-1 producers were also enterotoxigenic with staphylococcal enterotoxin C (SEC) most frequently elaborated as 46 (38.9%) strains were positive. However, 42 (35.5%) and 39 (32.5%) strains producing TSST-1 were also positive for SEA and SEB, respectively. It was concluded that TSST-1 producing strains of S. aureus are widespread in humans, animals and foods in Nigeria and such distribution may play some role in the epidemiology of toxic shock syndrome, the prevalence of which is currently unknown in the environment.
对从尼日利亚的人类、动物和食物中分离出的金黄色葡萄球菌菌株产生毒性休克综合征毒素-1（TSST-1）的频率进行了调查。在测试的1015株菌株中，120株（11.8%）TSST-1呈阳性。来自人类腹泻和伤口的194株菌株中有31株（16.0%）呈阳性，而来自8种动物的666株分离株中有47株（7.1%）呈阳性。山羊菌株中该毒素呈阳性的情况最为常见（17.0%）。来自食物的155株菌株中有42株（27.1%）TSST-1呈阳性。无论来源如何，噬菌体不可分型菌株（48.3%）在TSST-1产生菌中最为常见，其次是对多个噬菌体组敏感的菌株（混合组），占18.3%，以及噬菌体III组菌株（17.5%）。只有6株是噬菌体I组菌株（5.0%）。产生TSST-1的菌株大多对青霉素耐药。84株（70.0%）产生TSST-1的菌株也产肠毒素，其中以葡萄球菌肠毒素C（SEC）最为常见，46株（38.9%）菌株呈阳性。然而，产生TSST-1的菌株中分别有42株（35.5%）和39株（32.5%）SEA和SEB也呈阳性。得出的结论是，产生TSST-1的金黄色葡萄球菌菌株在尼日利亚的人类、动物和食物中广泛存在，这种分布可能在毒性休克综合征的流行病学中起一定作用，目前该综合征在当地环境中的流行情况尚不清楚。
