金黄色葡萄球菌双组分信号转导调控系统ArlRS对基因表达的全局调控
Global regulation of gene expression by ArlRS, a two-component signal transduction regulatory system of Staphylococcus aureus.
作者信息
Liang Xudong, Zheng Li, Landwehr Christina, Lunsford Dwayne, Holmes David, Ji Yinduo
机构信息
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave., St. Paul, MN 55108, USA.
出版信息
J Bacteriol. 2005 Aug;187(15):5486-92. doi: 10.1128/JB.187.15.5486-5492.2005.
Abstract
Staphylococcus aureus expresses various cell wall-associated and extracellular virulence factors, coordinately controlled by different two-component signal transduction systems and transcriptional regulators. In this study, we used microarray technology to identify the genes regulated by ArlR. The microarray data indicate that ArlR functions as a positive regulator and also as a negative repressor to directly and/or indirectly mediate the expression of at least 114 genes involved in different functions, including autolysis, cell division, growth, and pathogenesis.
摘要
金黄色葡萄球菌表达多种与细胞壁相关的和细胞外毒力因子，这些因子由不同的双组分信号转导系统和转录调节因子协同控制。在本研究中，我们使用微阵列技术来鉴定受ArlR调控的基因。微阵列数据表明，ArlR作为一种正调节因子，同时也作为一种负阻遏物，直接和/或间接介导至少114个参与不同功能（包括自溶、细胞分裂、生长和致病机制）的基因的表达。
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