Clark R G, Hartley W J, Burgess G S, Cameron J S, Mitchell G
Ruakura Animal Health Laboratory, Private Bag, Hamilton, New Zealand.
N Z Vet J. 1982 Jul;30(7):102-3. doi: 10.1080/00480169.1982.34897.
A cerebellar neuroaxonal dystrophy in working collie sheep dogs from two properties in New Zealand and one property in Australia is described. Clinical signs developed from 2-4 months of age and included hypermetria, wide-based stance, difficulty in maintaining balance, intention tremor and ataxia. Numerous spheroids, associated with mild Wallerian degeneration, were present in the central cerebellar, adjacent peduncular and folia white matter, and associated cerebellar roof and lateral vestibular nuclei. The history of several affected pups in litters from successive matings of the same sire and dam is suggestive of an autosomal recessive mode of inheritance.
本文描述了来自新西兰两个牧场和澳大利亚一个牧场的工作柯利牧羊犬中发生的一种小脑神经轴突营养不良症。临床症状在2至4月龄时出现，包括动作过度、宽基站姿、难以保持平衡、意向性震颤和共济失调。在小脑中央、相邻的脑桥和小脑叶片白质以及相关的小脑顶和外侧前庭核中存在大量与轻度华勒氏变性相关的球状小体。同一父系和母系连续交配所产幼犬中有几只患病幼犬，这一情况提示其遗传方式为常染色体隐性遗传。
