一只患有神经轴突营养不良的腊肠犬杂交犬的病理检查结果。
Pathological findings in a Dachshund-cross dog with neuroaxonal dystrophy.
作者信息
Pintus Davide, Cancedda Maria Giovanna, Macciocu Simona, Contu Claudia, Ligios Ciriaco
机构信息
Istituto Zooprofilattico Sperimentale della Sardegna "G.Pegreffi", Via Duca degli Abruzzi 8, 07100, Sassari, Italy.
出版信息
Acta Vet Scand. 2016 Jun 7;58(1):37. doi: 10.1186/s13028-016-0218-3.
BACKGROUND
Neuroaxonal dystrophy (NAD) is a neurodegenerative condition affecting humans and animals characterized by the widespread presence of swollen axons (spheroids).
CASE PRESENTATION
Herein, we report the pathological findings in a case of neuroaxonal dystrophy in a Dachshund-cross puppy, which was euthanized because of a proprioceptive positioning deficits and irreversible ataxia of the hind limbs. Histologically, there was a bilaterally symmetric neuroaxonal dystrophy with eosinophilic axonal spheroids exclusively localized at the level of the ventral posterior lateral nucleus of the thalamus, medial lemniscus, gracilis nucleus, medial cuneatus nucleus in the brain as well as the gracilis and cuneatus fasciculi throughout the spinal cord.
CONCLUSION
To the authors' knowledge, this is the first report of canine neuroaxonal dystrophy with this exclusive and specific localization only in the neuronal circuit implicated in the transmission of conscious proprioceptive information.
背景
神经轴索性营养不良（NAD）是一种影响人类和动物的神经退行性疾病，其特征是广泛存在肿胀的轴突（球体）。
病例报告
在此，我们报告一例腊肠犬杂交幼犬神经轴索性营养不良的病理发现，该幼犬因本体感觉定位缺陷和后肢不可逆共济失调而实施安乐死。组织学检查发现，存在双侧对称性神经轴索性营养不良，嗜酸性轴突球体仅局限于丘脑腹后外侧核、内侧丘系、薄束核、内侧楔束核水平，以及整个脊髓的薄束和楔束。
结论
据作者所知，这是首例仅在参与有意识本体感觉信息传递的神经回路中出现这种独特且特定定位的犬神经轴索性营养不良的报告。
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